首页> Alzheimer's & dementia (New York, N. Y.)> The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical <i>PSEN1</i> E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer's disease, including a placebo-treated noncarrier cohort.

The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical <i>PSEN1</i> E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer's disease, including a placebo-treated noncarrier cohort.

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第一作者： Pierre N,Tariot

第一单位： Banner Alzheimer's Institute, Phoenix, AZ, USA.

作者： Pierre N,Tariot ^[1] ; Francisco,Lopera ^[2] ; Jessica B,Langbaum ^[1] ; Ronald G,Thomas ^[3] ; Suzanne,Hendrix ^[4] ; Lon S,Schneider ^[5] ; Silvia,Rios-Romenets ^[2] ; Margarita,Giraldo ^[2] ; Natalia,Acosta ^[2] ; Carlos,Tobon ^[2] ; Claudia,Ramos ^[2] ; Alejandro,Espinosa ^[2] ; William,Cho ^[6] ; Michael,Ward ^[6] ; David,Clayton ^[6] ; Michael,Friesenhahn ^[6] ; Howard,Mackey ^[6] ; Lee,Honigberg ^[6] ; Sandra,Sanabria Bohorquez ^[6] ; Kewei,Chen ^[1] ; Trisha,Walsh ^[1] ; Carolyn,Langlois ^[1] ; Eric M,Reiman ^[1] ; Alzheimer's Prevention Initiative

作者单位： Banner Alzheimer's Institute, Phoenix, AZ, USA. ^[1] Grupo de Neurociencias, Universidad de Antioquia, SIU, Medellín, Colombia. ^[2] Department of Neurosciences, University of California San Diego School of Medicine, La Jolla, CA, USA. ^[3] Pentara Corporation, Salt Lake City, UT, USA. ^[4] USC State of California Alzheimer's Disease Research and Clinical Center, Keck Medicine of USC, Los Angeles, CA, USA. ^[5] Genentech, a Member of the Roche Group, South San Francisco, CA, USA. ^[6]

关键词 Alzheimer's Prevention Initiative Alzheimer's disease Autosomal-dominant Alzheimer's disease Clinical trial Crenezumab Preclinical Alzheimer's disease Prevention

DOI 10.1016/j.trci.2018.02.002

PMID 29955659

发布时间 2024-05-25

基金项目

P30 AG019610/AG/NIA NIH HHS/United States R01 AG055444/AG/NIA NIH HHS/United States RF1 AG041705/AG/NIA NIH HHS/United States UF1 AG046150/AG/NIA NIH HHS/United States

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