Identification of Cosalane as an Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling via a High-Throughput Screen.

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第一作者： Emily A,Hull-Ryde

第一单位： 1 Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.;2 Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

作者： Emily A,Hull-Ryde ^[1] ; Melissa A,Porter ^[2] ; Kenneth A,Fowler ^[3] ; Dmitri,Kireev ^[4] ; Kelin,Li ^[4] ; Catherine D,Simpson ^[4] ; Maria F,Sassano ^[5] ; Mark J,Suto ^[6] ; Kenneth H,Pearce ^[4] ; William,Janzen ^[7] ; James M,Coghill ^[3]

作者单位： 1 Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.;2 Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, NC, USA. ^[1] 1 Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.;3 Ribometrix, Inc., Durham, NC, USA. ^[2] 4 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ^[3] 1 Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ^[4] 2 Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, NC, USA.;5 Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA. ^[5] 6 Southern Research Institute, Birmingham, AL, USA. ^[6] 1 Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.;7 Epizyme, Inc., Cambridge, MA, USA. ^[7]

关键词 CC–chemokine receptor 7 G protein–coupled receptors chemotaxis assays cosalane high-throughput screen

主题词动物(Animals);金精三羧酸(Aurintricarboxylic Acid);细胞系(Cell Line);趋化作用(Chemotaxis);药物设计(Drug Design);高通量筛选分析(High-Throughput Screening Assays);人类(Humans);配体(Ligands);小鼠(Mice);分子结构(Molecular Structure);受体, CCR7(Receptors, CCR7);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);信号传导(Signal Transduction);构效关系(Structure-Activity Relationship);T淋巴细胞(T-Lymphocytes)

DOI 10.1177/2472555218780917

PMID 29958052

发布时间 2022-08-30

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SLAS discovery

2018年23卷10期

1083-1091页

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Identification of Cosalane as an Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling via a High-Throughput Screen.

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Identification of Cosalane as an Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling via a High-Throughput Screen.

SLAS discovery

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SLAS discovery

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