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首页> Molecular carcinogenesis> Inhibition of euchromatin histone-lysine N-methyltransferase 2 sensitizes breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through reactive oxygen species-mediated activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway activation.

Inhibition of euchromatin histone-lysine N-methyltransferase 2 sensitizes breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through reactive oxygen species-mediated activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway activation.

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作者： So Young,Kim ^[1] ; MiNa,Hong ^[1] ; Seung-Ho,Heo ^[2] ; Sojung,Park ^[1] ; Taeg Kyu,Kwon ^[3] ; Young Hoon,Sung ^[1] ; Yumin,Oh ^[4] ; Seulki,Lee ^[5] ; Gwan-Su,Yi ^[5] ; Inki,Kim ^[6]

作者单位： ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, Republic of Korea. ^[1] Department of Convergence Medicine, ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, Republic of Korea. ^[2] Department of Immunology, School of Medicine, Keimyung University, Daegu, Republic of Korea. ^[3] Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea. ^[4] Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland. ^[5] Department of Bio and Brain Engineering, KAIST, Daejeon, Republic of Korea. ^[6]

关键词 CHOP DR5 TRAIL human breast cancer cells

主题词转录激活因子4(Activating Transcription Factor 4);动物(Animals);细胞凋亡(Apoptosis);吖庚因类(Azepines);乳腺肿瘤(Breast Neoplasms);CCAAT增强子结合蛋白类(CCAAT-Enhancer-Binding Proteins);半胱氨酸天冬氨酸蛋白酶8(Caspase 8);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);组织相容性抗原(Histocompatibility Antigens);组蛋白赖氨酸N-甲基转移酶(Histone-Lysine N-Methyltransferase);人类(Humans);小鼠(Mice);模型, 生物学(Models, Biological);喹唑啉类(Quinazolines);活性氧(Reactive Oxygen Species);受体, TNF相关凋亡诱导配体(Receptors, TNF-Related Apoptosis-Inducing Ligand);TNF相关凋亡诱导配体(TNF-Related Apoptosis-Inducing Ligand);转录因子CHOP(Transcription Factor CHOP)

DOI 10.1002/mc.22872

PMID 29964331

发布时间 2019-05-06

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Molecular carcinogenesis

Molecular carcinogenesis

2018年57卷11期

1492-1506页

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