A Bayesian model to estimate the cutoff and the clinical utility of a biomarker assay.

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第一作者： Eleni,Vradi

第一单位： 1 Department of Research and Clinical Sciences Statistics, Bayer AG, Berlin, Germany and Competence Center for Clinical Trials, University of Bremen, Germany.

作者： Eleni,Vradi ^[1] ; Thomas,Jaki ^[2] ; Richardus,Vonk ^[3] ; Werner,Brannath ^[1]

作者单位： 1 Department of Research and Clinical Sciences Statistics, Bayer AG, Berlin, Germany and Competence Center for Clinical Trials, University of Bremen, Germany. ^[1] 2 Competence Center for Clinical Trials, University of Bremen, Bremen, Germany. ^[2] 3 Department of Mathematics and Statistics, Lancaster University, Lancaster, Lancashire LA14YF, UK. ^[3]

关键词 Bayesian model clinical utility cutoff estimation diagnostic tests predictive values response rates step function

主题词贝叶斯定理(Bayes Theorem);计算机模拟(Computer Simulation);诊断试验, 常规(Diagnostic Tests, Routine);终点测定(Endpoint Determination);人类(Humans);试验预期值(Predictive Value of Tests)

DOI 10.1177/0962280218784778

PMID 29966502

发布时间 2021-01-09

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