Altered reward-related neural responses in non-manifesting carriers of the Parkinson disease related LRRK2 mutation.

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作者： Avner,Thaler ^[1] ; Tal,Gonen ^[2] ; Anat,Mirelman ^[3] ; Rick C,Helmich ^[4] ; Tanya,Gurevich ^[5] ; Avi,Orr-Urtreger ^[6] ; Bastiaan R,Bloem ^[7] ; Nir,Giladi ^[8] ; Talma,Hendler ^[9] ; LRRK2 Ashkenazi Jewish consortium ^[10]

作者单位： Movement Disorders Unit, Neurological Institute, Tel-Aviv Sourasky Medical Center, 6 Weizman Street, 64239, Tel-Aviv, Israel. avnerth@gmail.com. ^[1] Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. avnerth@gmail.com. ^[2] Functional Brain Center, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel. avnerth@gmail.com. ^[3] Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, Israel. avnerth@gmail.com. ^[4] Functional Brain Center, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel. ^[5] Department of Neurosurgery, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel. ^[6] Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. ^[7] Laboratory of Early Markers of Neurodegeneration, Tel-Aviv Medical Center, Tel Aviv, Israel. ^[8] Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. ^[9] Movement Disorders Unit, Neurological Institute, Tel-Aviv Sourasky Medical Center, 6 Weizman Street, 64239, Tel-Aviv, Israel. ^[10] Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, Israel. ^[11] Genetic Institute, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel. ^[12]

关键词 Anticipation Genomic vulnerability LRRK2 Reward fMRI