Disruption of maternal gut microbiota during gestation alters offspring microbiota and immunity.

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作者： Donald D,Nyangahu ^[1] ; Katie S,Lennard ^[2] ; Bryan P,Brown ^[3] ; Matthew G,Darby ^[4] ; Jerome M,Wendoh ^[2] ; Enock,Havyarimana ^[1] ; Peter,Smith ^[1] ; James,Butcher ^[1] ; Alain,Stintzi ^[1] ; Nicola,Mulder ^[5] ; William,Horsnell ^[5] ; Heather B,Jaspan ^[3]

作者单位： Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, Division of Immunology, University of Cape Town, Cape Town, South Africa. ^[1] Present Address: Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA. ^[2] Institute of Infectious Diseases and Molecular Medicine, Department of Integrative Biomedical Sciences, Division of Computational Biology, University of Cape Town, Cape Town, South Africa. ^[3] Duke University, Durham, NC, USA. ^[4] Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ontario, CA, USA. ^[5] Institute of Microbiology and Infection, University of Birmingham, Birmingham, B15 2TT, UK. ^[6] Laboratory of Molecular and Experimental Immunology and Neurogenetics, UMR 7355, CNRS-University of Orleans and Le Studium Institute for Advanced Studies, Rue Dupanloup, 45000, Orléans, France. ^[7] Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, Division of Immunology, University of Cape Town, Cape Town, South Africa. hbjaspan@gmail.com. ^[8] Department of Pediatrics and Global Health, University of Washington and Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA. hbjaspan@gmail.com. ^[9]

主题词适应性免疫(Adaptive Immunity);动物(Animals);动物, 新生(Animals, Newborn);抗菌药(Anti-Bacterial Agents);抗体, 细菌(Antibodies, Bacterial);B-淋巴细胞(B-Lymphocytes);母乳喂养(Breast Feeding);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);女(雌)性(Female);免疫球蛋白G(Immunoglobulin G);免疫球蛋白M(Immunoglobulin M);肠(Intestines);淋巴细胞计数(Lymphocyte Count);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);妊娠(Pregnancy);万古霉素(Vancomycin)

DOI 10.1186/s40168-018-0511-7

PMID 29981583

发布时间 2019-01-28

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Microbiome

2018年6卷1期

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Disruption of maternal gut microbiota during gestation alters offspring microbiota and immunity.

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Disruption of maternal gut microbiota during gestation alters offspring microbiota and immunity.

Microbiome

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