首页> The Journal of biological chemistry> Nitric oxide promotes cancer cell dedifferentiation by disrupting an Oct4:caveolin-1 complex: A new regulatory mechanism for cancer stem cell formation.

Nitric oxide promotes cancer cell dedifferentiation by disrupting an Oct4:caveolin-1 complex: A new regulatory mechanism for cancer stem cell formation.

导出 OA

翻译打印收藏纠错

第一作者： Arnatchai,Maiuthed

第一单位： From the Department of Pharmacology and Physiology.;Cell-based Drug and Health Products Development Research Unit, Faculty of Pharmaceutical Sciences.

作者： Arnatchai,Maiuthed ^[1] ; Narumol,Bhummaphan ^[2] ; Sudjit,Luanpitpong ^[3] ; Apiwat,Mutirangura ^[4] ; Chatchawit,Aporntewan ^[5] ; Arthitaya,Meeprasert ^[6] ; Thanyada,Rungrotmongkol ^[7] ; Yon,Rojanasakul ^[8] ; Pithi,Chanvorachote ^[9]

作者单位： From the Department of Pharmacology and Physiology.;Cell-based Drug and Health Products Development Research Unit, Faculty of Pharmaceutical Sciences. ^[1] Cell-based Drug and Health Products Development Research Unit, Faculty of Pharmaceutical Sciences.;the Inter-Department Program of Biomedical Sciences, Faculty of Graduate School, Chulalongkorn University, Bangkok 10330, Thailand. ^[2] the Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700 Thailand, and. ^[3] the Center of Excellence in Molecular Genetics of Cancer and Human Diseases, Department of Anatomy, Faculty of Medicine, and. ^[4] the Department of Mathematics and Computer Science. ^[5] Structural and Computational Biology Research Group, and Department of Biochemistry, Faculty of Science. ^[6] Structural and Computational Biology Research Group, and Department of Biochemistry, Faculty of Science.;Ph.D. Program in Bioinformatics and Computational Biology. ^[7] WVU Cancer Institute, West Virginia University, Morgantown, West Virginia 26506. ^[8] From the Department of Pharmacology and Physiology, pithi.ch@gmail.com pithi.c@chula.ac.th.;Cell-based Drug and Health Products Development Research Unit, Faculty of Pharmaceutical Sciences. ^[9]

关键词 GSK3β OCT4 cancer biology cancer stem cells caveolin cell signaling differentiation lung cancer nitric oxide, caveolin-1 proteasome protein degradation protein–protein interaction regulation