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首页> The Journal of biological chemistry> The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca<sup>2+</sup>-ATPase, is a major determinant of Ca<sup>2+</sup> alternans in intact mouse hearts.

The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca<sup>2+</sup>-ATPase, is a major determinant of Ca<sup>2+</sup> alternans in intact mouse hearts.

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作者： Bo,Sun ^[1] ; Jinhong,Wei ^[1] ; Xiaowei,Zhong ^[1] ; Wenting,Guo ^[1] ; Jinjing,Yao ^[1] ; Ruiwu,Wang ^[1] ; Alexander,Vallmitjana ^[2] ; Raul,Benitez ^[2] ; Leif,Hove-Madsen ^[3] ; S R Wayne,Chen ^[4]

作者单位： From the Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada. ^[1] the Department of Automatic Control, Universitat Politècnica de Catalunya, Barcelona 08034, Spain, and. ^[2] the Biomedical Research Institute of Barcelona (IIBB), CSIC, Sant Pau, Hospital de Sant Pau, Barcelona 08025, Spain. ^[3] From the Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada, swchen@ucalgary.ca. ^[4]

关键词 Ca2+ alternans Ca2+ release refractoriness calcium calcium ATPase calcium imaging calcium intracellular release cardiac dysfunction confocal Ca2+ imaging endoplasmic reticulum (ER)intact heart imaging phospholamban ryanodine receptor sarcoplasmic reticulum (SR)ventricular tachyarrhythmia

主题词动物(Animals);钙(Calcium);钙信号(Calcium Signaling);钙结合蛋白质类(Calcium-Binding Proteins);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);心肌(Myocardium);点突变(Point Mutation);兰尼碱受体钙释放通道(Ryanodine Receptor Calcium Release Channel);肌浆网钙转运ATP酶类(Sarcoplasmic Reticulum Calcium-Transporting ATPases)

DOI 10.1074/jbc.RA118.003760

PMID 29986885

发布时间 2021-02-05

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The Journal of biological chemistry

The Journal of biological chemistry

2018年293卷35期

13650-13661页

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