Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium.
作者:
Jordi,Merino [1]
;
Hassan S,Dashti [2]
;
Sherly X,Li [3]
;
Chloé,Sarnowski [1]
;
Anne E,Justice [2]
;
Misa,Graff [4]
;
Constantina,Papoutsakis [5]
;
Caren E,Smith [6]
;
George V,Dedoussis [7]
;
Rozenn N,Lemaitre [7]
;
Mary K,Wojczynski [8]
;
Satu,Männistö [9]
;
Julius S,Ngwa [10]
;
Minjung,Kho [11]
;
Tarunveer S,Ahluwalia [12]
;
Natalia,Pervjakova [13]
;
Denise K,Houston [5]
;
Claude,Bouchard [14]
;
Tao,Huang [15]
;
Marju,Orho-Melander [16]
;
Alexis C,Frazier-Wood [13]
;
Dennis O,Mook-Kanamori [17]
;
Louis,Pérusse [18]
;
Craig E,Pennell [19]
;
Paul S,de Vries [20]
;
Trudy,Voortman [21]
;
Olivia,Li [22]
;
Stavroula,Kanoni [23]
;
Lynda M,Rose [24]
;
Terho,Lehtimäki [25]
;
Jing Hua,Zhao [26]
;
Mary F,Feitosa [27]
;
Jian'an,Luan [28]
;
Nicola M,McKeown [29]
;
Jennifer A,Smith [30]
;
Torben,Hansen [31]
;
Niina,Eklund [32]
;
Mike A,Nalls [33]
;
Tuomo,Rankinen [34]
;
Jinyan,Huang [35]
;
Dena G,Hernandez [4]
;
Christina-Alexandra,Schulz [12]
;
Ani,Manichaikul [4]
;
Ruifang,Li-Gao [36]
;
Marie-Claude,Vohl [15]
;
Carol A,Wang [16]
;
Frank J A,van Rooij [13]
;
Jean,Shin [37]
;
Ioanna P,Kalafati [38]
;
Felix,Day [21]
;
Paul M,Ridker [39]
;
Mika,Kähönen [38]
;
David S,Siscovick [23]
;
Claudia,Langenberg [40]
;
Wei,Zhao [25]
;
Arne,Astrup [28]
;
Paul,Knekt [41]
;
Melissa,Garcia [29]
;
D C,Rao [31]
;
Qibin,Qi [32]
;
Luigi,Ferrucci [10]
;
Ulrika,Ericson [4]
;
John,Blangero [34]
;
Albert,Hofman [42]
;
Zdenka,Pausova [35]
;
Vera,Mikkilä [43]
;
Nick J,Wareham [4]
;
Sharon L R,Kardia [15]
;
Oluf,Pedersen [44]
;
Antti,Jula [13]
;
Joanne E,Curran [45]
;
M Carola,Zillikens [46]
;
Jorma S,Viikari [47]
;
Nita G,Forouhi [48]
;
José M,Ordovás [23]
;
John C,Lieske [49]
;
Harri,Rissanen [31]
;
André G,Uitterlinden [50]
;
Olli T,Raitakari [32]
;
Jessica C,Kiefte-de Jong [51]
;
Josée,Dupuis [52]
;
Jerome I,Rotter [4]
;
Kari E,North [15]
;
Robert A,Scott [16]
;
Michael A,Province [13]
;
Markus,Perola [49]
;
L Adrienne,Cupples [53]
;
Stephen T,Turner [54]
;
Thorkild I A,Sørensen [55]
;
Veikko,Salomaa [4]
;
Yongmei,Liu [9]
;
Yun J,Sung [56]
;
Lu,Qi [57]
;
Stefania,Bandinelli [58]
;
Stephen S,Rich [13]
;
Renée,de Mutsert [31]
;
Angelo,Tremblay [53]
;
Wendy H,Oddy [59]
;
Oscar H,Franco [60]
;
Tomas,Paus [31]
;
Jose C,Florez [61]
;
Panos,Deloukas [5]
;
Leo-Pekka,Lyytikäinen [62]
;
Daniel I,Chasman [63]
;
Audrey Y,Chu [7]
;
Toshiko,Tanaka [64]
作者单位:
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
[1]
Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[2]
Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
[3]
MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
[4]
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[5]
Biomedical and Translational Informatics Institute, Geisinger Health Weis Center for Research, Danvilla, PA, USA.
[6]
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
[7]
Research International and Scientific Affairs, Academy of Nutrition and Dietetics, Chicago, IL, USA.
[8]
Nutrition and Genomics, JM-USDA-HNRCA at Tufts University, Boston, MA, USA.
[9]
Department of Dietetics and Nutritional Science, School of Health Science and Education, Harokopio University, Athens, Greece.
[10]
Departments of Medicine, University of Washington, Seattle, USA.
[11]
Department of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
[12]
National Institute for Health and Welfare, Helsinki, Finland.
[13]
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
[14]
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
[15]
Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[16]
Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
[17]
Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
[18]
Genomics of Common Disease, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
[19]
Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC, USA.
[20]
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
[21]
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Peking, China.
[22]
Department of Clinical Sciences, Lund University Diabetes Center, Lund University, Malmö, Sweden.
[23]
USDA/ARS Children's Nutrition Research Center, Houston, TX, USA.
[24]
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
[25]
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
[26]
Department of Kinesiology, Faculty of Medicine, Laval University, Québec, Canada.
[27]
Institute of Nutrition and Functional Foods, Québec, Canada.
[28]
School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Callaghan, Australia.
[29]
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
[30]
Department of Epidemiology, Erasmus MC University Hospital, Rotterdam, The Netherlands.
[31]
The Hospital for Sick Children, Translational Medicine, University of Toronto, Toronto, Canada.
[32]
William Harvey Research Institute, Queen Mary University of London, London, UK.
[33]
Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
[34]
Department of Clinical Chemistry, Fimlab Laboratories, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
[35]
Nutritional Epidemiology, JM-USDA-HNRCA at Tufts University, Boston, MA, USA.
[36]
Data Tecnica International, Glen Echo, MD, USA.
[37]
Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
[38]
Department of Bioinformatics, Shanghai Institute of Hematology, Shanghai, China.
[39]
Center for Public Health Genomics, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, VA, USA.
[40]
School of Nutrition, Laval University, Québec, Canada.
[41]
Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
[42]
New York Academy of Medicine, New York, NY, USA.
[43]
Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
[44]
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
[45]
Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
[46]
Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
[47]
Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
[48]
South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX, USA.
[49]
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
[50]
Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Canada.
[51]
Department of Food and Environmental Sciences, Division of Nutrition, Helsinki, Finland.
[52]
Department of Internal Medicine, Erasmus MC University Hospital, Rotterdam, The Netherlands.
[53]
Division of Medicine, Turku University Hospital, Turku, Finland.
[54]
Department of Medicine, University of Turku, Turku, Finland.
[55]
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
[56]
IMDEA Food Institute, CEI UAM + CSIC, Madrid, Spain.
[57]
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
[58]
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
[59]
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
[60]
Global Public Health, Leiden University College, The Hague, The Netherlands.
[61]
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
[62]
Departments of Pediatrics and Medicine, Division of Genomic Outcomes, Harbor-UCLA Medical Center, Torrance, CA, USA.
[63]
Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.
[64]
NHLBI Framingham Heart Study, Framingham, MA, USA.
[65]
Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[66]
Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC, USA.
[67]
Department of Epidemiology, Tulane University, New Orleans, LA, USA.
[68]
Geriatric Unit, Azienda Sanitaria Firenze-ASF, Florence, Italy.
[69]
Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
[70]
Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia.
[71]
Menzies Institute for Medical Research, University of Tasmania, Tasmania, Australia.
[72]
Rotman Research Institute, University of Toronto, Toronto, Canada.
[73]
Department of Psychiatry and Psychology, University of Toronto, Toronto, Canada.
[74]
Child Mind Institute, New York, NY, USA.
[75]
Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.
[76]
Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
[77]
Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA. tanakato@mail.nih.gov.
[78]
主题词
老年人(Aged);衰老(Aging);队列研究(Cohort Studies);能量摄取(Energy Intake);女(雌)性(Female);成纤维细胞生长因子(Fibroblast Growth Factors);基因座(Genetic Loci);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);基因组学(Genomics);基因型(Genotype);心脏病(Heart Diseases);人类(Humans);男(雄)性(Male);膜蛋白质类(Membrane Proteins);中年人(Middle Aged);肥胖症(Obesity);多态性, 单核苷酸(Polymorphism, Single Nucleotide);受体, 维甲酸(Receptors, Retinoic Acid)
DOI
10.1038/s41380-018-0079-4
PMID
29988085
发布时间
2022-12-07
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Molecular psychiatry
Molecular psychiatry
1920-1932页
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