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Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development.

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第一作者： Thomas,Gross

第一单位： Translational Laboratory and Biorepository, University of California, Irvine School of Medicine, Irvine, CA 92697, United States.;Department of Anatomy & Neurobiology, University of California, Irvine School of Medicine, Irvine, CA 92697, United States.

作者： Thomas,Gross ^[1] ; Mark,Mapstone ^[2] ; Ricardo,Miramontes ^[2] ; Robert,Padilla ^[2] ; Amrita K,Cheema ^[3] ; Fabio,Macciardi ^[4] ; Howard J,Federoff ^[5] ; Massimo S,Fiandaca ^[6]

作者单位： Translational Laboratory and Biorepository, University of California, Irvine School of Medicine, Irvine, CA 92697, United States.;Department of Anatomy & Neurobiology, University of California, Irvine School of Medicine, Irvine, CA 92697, United States. ^[1] Translational Laboratory and Biorepository, University of California, Irvine School of Medicine, Irvine, CA 92697, United States.;Department of Neurology, University of California, Irvine School of Medicine, Irvine, CA 92697, United States. ^[2] Department of Oncology, Georgetown University Medical Center, Washington DC, 20007, United States.;Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, 20007, United States. ^[3] Translational Laboratory and Biorepository, University of California, Irvine School of Medicine, Irvine, CA 92697, United States.;Department of Psychiatry and Human Behavior, University of California, Irvine School of Medicine, Irvine, CA 92697, United States. ^[4] Translational Laboratory and Biorepository, University of California, Irvine School of Medicine, Irvine, CA 92697, United States.;Department of Neurology, University of California, Irvine School of Medicine, Irvine, CA 92697, United States.;UCI Health, University of California, Irvine School of Medicine, Irvine, CA 92697, United States. ^[5] Translational Laboratory and Biorepository, University of California, Irvine School of Medicine, Irvine, CA 92697, United States.;Department of Anatomy & Neurobiology, University of California, Irvine School of Medicine, Irvine, CA 92697, United States.;Department of Neurology, University of California, Irvine School of Medicine, Irvine, CA 92697, United States.;Department of Neurological Surgery, University of California, Irvine School of Medicine, Irvine, CA 92697, United States. ^[6]

关键词 Biomarker Data Pre-processing Exploratory data analysis LOD Machine learning Small biological datasets Targeted metabolomics.

医学主题词人类(Humans);代谢组学(Metabolomics);表型(Phenotype);结果可重复性(Reproducibility of Results)

DOI 10.2174/1568026618666180711144323

PMID 29992885

发布时间 2023-07-01

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