Autophagy-deficient tumor cells rely on extracellular amino acids to survive upon glutamine deprivation.

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第一作者： Nan,Zhang

第一单位： a Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology , School of Basic Medical Sciences, Peking University Health Science Center , Beijing , China.

作者： Nan,Zhang ^[1] ; Xin,Yang ^[1] ; Fengjie,Yuan ^[1] ; Wei-Guo,Zhu ^[1] ; Ying,Zhao ^[2]

作者单位： a Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology , School of Basic Medical Sciences, Peking University Health Science Center , Beijing , China. ^[1] b School of Medicine , Shenzhen University , Shenzhen , China. ^[2]

关键词 ATF4 Amino acids uptake NFE2L2 SIRT6 autophagy glutamine

主题词氨基酸类(Amino Acids);自噬(Autophagy);细胞存活(Cell Survival);谷氨酰胺(Glutamine);内环境稳定(Homeostasis)

DOI 10.1080/15548627.2018.1493314

PMID 29995581

发布时间 2019-08-04

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