Probing Substituents in the 1- and 3-Position: Tetrahydropyrazino-Annelated Water-Soluble Xanthine Derivatives as Multi-Target Drugs With Potent Adenosine Receptor Antagonistic Activity.

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作者： Pierre,Koch ^[1] ; Andreas,Brunschweiger ^[1] ; Vigneshwaran,Namasivayam ^[1] ; Stefan,Ullrich ^[1] ; Annalisa,Maruca ^[2] ; Beatrice,Lazzaretto ^[1] ; Petra,Küppers ^[1] ; Sonja,Hinz ^[1] ; Jörg,Hockemeyer ^[1] ; Michael,Wiese ^[3] ; Jag,Heer ^[4] ; Stefano,Alcaro ^[2] ; Katarzyna,Kiec-Kononowicz ^[5] ; Christa E,Müller ^[1]

作者单位： PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, Bonn, Germany. ^[1] Dipartimento di Scienze della Salute, Università degli Studi "Magna Græcia" di Catanzaro, Catanzaro, Italy. ^[2] Pharmaceutical Institute, Pharmaceutical Chemistry II, University of Bonn, Bonn, Germany. ^[3] UCB Celltech, UCB Pharma S.A., Slough, United Kingdom. ^[4] Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland. ^[5]

关键词 Alzheimer's disease Parkinson's disease adenosine A1 receptor antagonists adenosine A2A receptor antagonists anellated xanthines caffeine derivatives monoamine oxidase (MAO) B inhibitors tetrahydropyrazino[2, 1-f]purinediones

DOI 10.3389/fchem.2018.00206

PMID 29998095

发布时间 2020-10-01

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Frontiers in chemistry

2018年6卷

206页

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Probing Substituents in the 1- and 3-Position: Tetrahydropyrazino-Annelated Water-Soluble Xanthine Derivatives as Multi-Target Drugs With Potent Adenosine Receptor Antagonistic Activity.

Frontiers in chemistry

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Probing Substituents in the 1- and 3-Position: Tetrahydropyrazino-Annelated Water-Soluble Xanthine Derivatives as Multi-Target Drugs With Potent Adenosine Receptor Antagonistic Activity.

Frontiers in chemistry

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Frontiers in chemistry

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