Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress.-论文-万方医学网

作者： Krissie,Lenting ^[1] ; Mohammed,Khurshed ^[2] ; Tom H,Peeters ^[3] ; Corina N A M,van den Heuvel ^[4] ; Sanne A M,van Lith ^[1] ; Tessa,de Bitter ^[2] ; Wiljan,Hendriks ^[2] ; Paul N,Span ^[2] ; Remco J,Molenaar ^[5] ; Dennis,Botman ^[6] ; Kiek,Verrijp ^[3] ; Arend,Heerschap ^[3] ; Mark,Ter Laan ^[2] ; Benno,Kusters ^[4] ; Anne,van Ewijk ^[7] ; Martijn A,Huynen ^[2] ; Cornelis J F,van Noorden ^[1] ; William P J,Leenders ^[8]

作者单位： Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands. ^[1] Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands. ^[2] Department of Medical Biology, Cancer Center Amsterdam, Academic Medical Centre, Amsterdam, The Netherlands. ^[3] Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. ^[4] Department of Cell Biology, Radboud Institute of Molecular Life Sciences, Nijmegen, The Netherlands. ^[5] Radiotherapy and Oncoimmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands. ^[6] Department of Neurosurgery, Radboud University Medical Center, Nijmegen, The Netherlands; and. ^[7] Center for Molecular and Biomolecular Informatics, Radboud Institute of Molecular Life Sciences, Nijmegen, The Netherlands. ^[8]

主题词 4-氨基丁酸转氨酶(4-Aminobutyrate Transaminase);动物(Animals);脑肿瘤(Brain Neoplasms);基因表达谱(Gene Expression Profiling);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);神经胶质瘤(Glioma);谷氨酸脱氢酶(Glutamate Dehydrogenase);谷氨酸(Glutamic Acid);谷氨酰胺酶(Glutaminase);人类(Humans);异柠檬酸脱氢酶(Isocitrate Dehydrogenase);乳酸(Lactic Acid);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);突变(Mutation);肿瘤侵润(Neoplasm Invasiveness);应激, 生理学(Stress, Physiological);琥珀酸半醛脱氢酶(Succinate-Semialdehyde Dehydrogenase);肿瘤细胞, 培养的(Tumor Cells, Cultured);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1096/fj.201800907RR

PMID 30001166

发布时间 2022-04-08

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Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress.

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Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress.

FASEB journal

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FASEB journal

相关期刊

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