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A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3.

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第一作者： Hannah M,Southam

第一单位： Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

作者： Hannah M,Southam ^[1] ; Thomas W,Smith ^[2] ; Rhiannon L,Lyon ^[1] ; Chunyan,Liao ^[1] ; Clare R,Trevitt ^[1] ; Laurence A,Middlemiss ^[2] ; Francesca L,Cox ^[2] ; Jonathan A,Chapman ^[2] ; Sherif F,El-Khamisy ^[1] ; Michael,Hippler ^[2] ; Michael P,Williamson ^[3] ; Peter J F,Henderson ^[4] ; Robert K,Poole ^[5]

作者单位： Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK. ^[1] Department of Chemistry, The University of Sheffield, Western Bank, Sheffield S3 7HF, UK. ^[2] Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK. Electronic address: m.williamson@sheffield.ac.uk. ^[3] School of Biomedical Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK. Electronic address: p.j.f.henderson@leeds.ac.uk. ^[4] Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK. Electronic address: r.poole@sheffield.ac.uk. ^[5]

关键词 CO-releasing molecules CORM-3 Gasotransmitters Metallo-drugs Novel antimicrobials

主题词抗菌药(Anti-Bacterial Agents);抗肿瘤药(Antineoplastic Agents);一氧化碳(Carbon Monoxide);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);大肠杆菌(Escherichia coli);大肠杆菌感染(Escherichia coli Infections);人类(Humans);肿瘤(Neoplasms);有机金属化合物(Organometallic Compounds);钌(Ruthenium)

DOI 10.1016/j.redox.2018.06.008

PMID 30007887

发布时间 2025-05-30

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Redox biology

2018年18卷

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A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3.

Redox biology

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Redox biology

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A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3.

Redox biology

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Redox biology

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