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首页> International journal of molecular sciences> Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions.

Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions.

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第一作者： Salvatore,Savino

第一单位： Department of Chemistry, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy. salvatoresavino.s@libero.it.

作者： Salvatore,Savino ^[1] ; Cristina,Marzano ^[2] ; Valentina,Gandin ^[3] ; James D,Hoeschele ^[4] ; Giovanni,Natile ^[5] ; Nicola,Margiotta ^[6]

作者单位： Department of Chemistry, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy. salvatoresavino.s@libero.it. ^[1] Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy. cristina.marzano@unipd.it. ^[2] Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy. valentina.gandin@unipd.it. ^[3] Department of Chemistry, Eastern Michigan University, Ypsilanti, MI 48197, USA. hoeschel@chemistry.msu.edu. ^[4] Department of Chemistry, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy. giovanni.natile@uniba.it. ^[5] Department of Chemistry, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy. nicola.margiotta@uniba.it. ^[6]

关键词 DNA cisplatin kiteplatin mitochondria platinum(IV) complexes tumor spheroids α-lipoic acid

主题词抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);顺铂(Cisplatin);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);人类(Humans);线粒体(Mitochondria);线粒体膜(Mitochondrial Membranes);分子结构(Molecular Structure);有机铂化合物(Organoplatinum Compounds);铂(Platinum);药物前体(Prodrugs);活性氧(Reactive Oxygen Species);硫辛酸(Thioctic Acid)

DOI 10.3390/ijms19072050

PMID 30011897

发布时间 2018-12-02

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International journal of molecular sciences

International journal of molecular sciences

2018年19卷7期

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