Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure.
第一作者:
Reshma S,Baliga
第一单位:
William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, EC1M 6BQ London, United Kingdom.
作者:
主题词
动物(Animals);细胞, 培养的(Cells, Cultured);环GMP(Cyclic GMP);环核苷酸磷酸二酯酶类, 2型(Cyclic Nucleotide Phosphodiesterases, Type 2);鸟苷酸环化酶(Guanylate Cyclase);心力衰竭(Heart Failure);男(雄)性(Male);小鼠(Mice);一氧化氮(Nitric Oxide);磷酸二酯酶抑制剂(Phosphodiesterase Inhibitors);信号传导(Signal Transduction)
DOI
10.1073/pnas.1800996115
PMID
30012589
发布时间
2022-01-29
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