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Delineating the role of cooperativity in the design of potent PROTACs for BTK.

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第一作者： Adelajda,Zorba

第一单位： Internal Medicine Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA 02139.;Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.

作者： Adelajda,Zorba ^[1] ; Chuong,Nguyen ^[2] ; Yingrong,Xu ^[2] ; Jeremy,Starr ^[2] ; Kris,Borzilleri ^[2] ; James,Smith ^[2] ; Hongyao,Zhu ^[3] ; Kathleen A,Farley ^[2] ; WeiDong,Ding ^[2] ; James,Schiemer ^[2] ; Xidong,Feng ^[2] ; Jeanne S,Chang ^[2] ; Daniel P,Uccello ^[2] ; Jennifer A,Young ^[2] ; Carmen N,Garcia-Irrizary ^[2] ; Lara,Czabaniuk ^[2] ; Brandon,Schuff ^[2] ; Robert,Oliver ^[2] ; Justin,Montgomery ^[2] ; Matthew M,Hayward ^[2] ; Jotham,Coe ^[2] ; Jinshan,Chen ^[2] ; Mark,Niosi ^[4] ; Suman,Luthra ^[5] ; Jaymin C,Shah ^[5] ; Ayman,El-Kattan ^[4] ; Xiayang,Qiu ^[2] ; Graham M,West ^[2] ; Mark C,Noe ^[2] ; Veerabahu,Shanmugasundaram ^[2] ; Adam M,Gilbert ^[2] ; Matthew F,Brown ^[2] ; Matthew F,Calabrese ^[6]

作者单位： Internal Medicine Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA 02139.;Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340. ^[1] Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340. ^[2] Computational Sciences, Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340. ^[3] Medicine Design, Pfizer Worldwide Research and Development, Groton, CT 06340. ^[4] Pharmaceutical Sciences Small Molecule, Pfizer Worldwide Research and Development, Cambridge, MA 02139. ^[5] Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340; matthew.calabrese@pfizer.com. ^[6]

关键词 BTK PROTAC catalytic proteasome targeted protein degradation