Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.-论文-万方医学网

第一作者： Saar,Vandekeere

第一单位： Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB, Leuven 3000, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, VIB-KU Leuven Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven 3000, Belgium.

作者： Saar,Vandekeere ^[1] ; Charlotte,Dubois ^[2] ; Joanna,Kalucka ^[2] ; Mark R,Sullivan ^[3] ; Melissa,García-Caballero ^[2] ; Jermaine,Goveia ^[2] ; Rongyuan,Chen ^[4] ; Frances F,Diehl ^[3] ; Libat,Bar-Lev ^[5] ; Joris,Souffreau ^[2] ; Andreas,Pircher ^[2] ; Saran,Kumar ^[5] ; Stefan,Vinckier ^[2] ; Yoshio,Hirabayashi ^[6] ; Shigeki,Furuya ^[7] ; Luc,Schoonjans ^[1] ; Guy,Eelen ^[2] ; Bart,Ghesquière ^[2] ; Eli,Keshet ^[5] ; Xuri,Li ^[8] ; Matthew G,Vander Heiden ^[9] ; Mieke,Dewerchin ^[10] ; Peter,Carmeliet ^[11]

作者单位： Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB, Leuven 3000, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, VIB-KU Leuven Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven 3000, Belgium. ^[1] Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB, Leuven 3000, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, VIB-KU Leuven Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven 3000, Belgium. ^[2] The Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. ^[3] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China. ^[4] Department of Developmental Biology and Cancer Research, The Hebrew University, Jerusalem 91120, Israel. ^[5] Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, Wako City, Saimata 351-0198, Japan. ^[6] Department of Bioscience and Biotechnology, Kyushu University, Fukuoka 812-8581, Japan. ^[7] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China. Electronic address: lixr6@mail.sysu.edu.cn. ^[8] The Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. ^[9] Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB, Leuven 3000, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, VIB-KU Leuven Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven 3000, Belgium. Electronic address: mieke.dewerchin@kuleuven.vib.be. ^[10] Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB, Leuven 3000, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, VIB-KU Leuven Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven 3000, Belgium. Electronic address: peter.carmeliet@kuleuven.vib.be. ^[11]

医学主题词细胞凋亡(Apoptosis);碳水化合物代谢障碍, 先天性(Carbohydrate Metabolism, Inborn Errors);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);营养保健品(Dietary Supplements);内皮细胞(Endothelial Cells);基因敲低技术(Gene Knockdown Techniques);血红素(Heme);氯化血红素(Hemin);人类(Humans);小头畸形(Microcephaly);线粒体(Mitochondria);新生血管化, 生理性(Neovascularization, Physiologic);氧化性应激(Oxidative Stress);磷酸甘油脱氢酶(Phosphoglycerate Dehydrogenase);蛋白质生物合成(Protein Biosynthesis);精神运动性障碍(Psychomotor Disorders);嘌呤类(Purines);活性氧(Reactive Oxygen Species);发作(Seizures);丝氨酸(Serine)

DOI 10.1016/j.cmet.2018.06.009

PMID 30017355

发布时间 2019-12-10

基金项目

T32 GM007287/GM/NIGMS NIH HHS/United States R01 CA201276/CA/NCI NIH HHS/United States R21 CA198028/CA/NCI NIH HHS/United States HHMI/Howard Hughes Medical Institute/United States

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Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.

Cell metabolism

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Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.

Cell metabolism

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Cell metabolism

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