Microstructural Distinction of Electrospun Nanofibrous Drug Delivery Systems Formulated with Different Excipients.

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第一作者： Adrienn,Kazsoki

第一单位： University Pharmacy Department of Pharmacy Administration , Semmelweis University , Hőgyes Endre utca 7-9 , H-1092 Budapest , Hungary.

作者： Adrienn,Kazsoki ^[1] ; Péter,Szabó ^[1] ; Attila,Domján ^[2] ; Attila,Balázs ^[2] ; Tamás,Bozó ^[3] ; Miklós,Kellermayer ^[3] ; Attila,Farkas ^[4] ; Diána,Balogh-Weiser ^[4] ; Balázs,Pinke ^[5] ; András,Darcsi ^[6] ; Szabolcs,Béni ^[6] ; János,Madarász ^[7] ; Lajos,Szente ^[8] ; Romána,Zelkó ^[1]

作者单位： University Pharmacy Department of Pharmacy Administration , Semmelweis University , Hőgyes Endre utca 7-9 , H-1092 Budapest , Hungary. ^[1] NMR Research Laboratory, Research Centre for Natural Sciences , Hungarian Academy of Sciences , Magyar tudósok körútja 2 , H-1117 Budapest , Hungary. ^[2] Department of Biophysics and Radiation Biology , Semmelweis University , Tűzoltó utca 37-47 , H-1094 Budapest , Hungary. ^[3] Department of Organic Chemistry and Technology , Budapest University of Technology and Economics , Műegyetem rakpart 3 , H-1111 Budapest , Hungary. ^[4] Department of Polymer Engineering, Faculty of Mechanical Engineering , Budapest University of Technology and Economics , Műegyetem rakpart 3 , H-1111 Budapest , Hungary. ^[5] Department of Pharmacognosy , Semmelweis University , Üllői út 26 , H-1085 Budapest , Hungary. ^[6] Department of Inorganic and Analytical Chemistry , Budapest University of Technology and Economics , Szent Gellért tér 4 , H-1111 Budapest , Hungary. ^[7] CycloLab , Cyclodextrin Research and Development Laboratory Ltd. , Illatos út 7 , H-1097 Budapest , Hungary. ^[8]

关键词 accelerated stability test electrospun nanofiber inner and outer plasticizer metoclopramide hydrochloride monohydrate morphological and solid-state characterization

主题词药物释放系统(Drug Delivery Systems);辅药(Excipients);磁共振波谱学(Magnetic Resonance Spectroscopy);甲氧氯普胺(Metoclopramide);显微镜检查, 原子力(Microscopy, Atomic Force);纳米纤维(Nanofibers);聚山梨醇酯类(Polysorbates)

DOI 10.1021/acs.molpharmaceut.8b00646

PMID 30024759

发布时间 2019-08-02

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