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首页> Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology> Midazolam Enhances Mutant Huntingtin Protein Accumulation via Impairment of Autophagic Degradation In Vitro.

Midazolam Enhances Mutant Huntingtin Protein Accumulation via Impairment of Autophagic Degradation In Vitro.

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第一作者： Jiqian,Zhang

第一单位： Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

作者： Jiqian,Zhang ^[1] ; Wei,Dai ^[1] ; Pengcheng,Geng ^[1] ; Li,Zhang ^[2] ; Qilian,Tan ^[1] ; Dan,Cheng ^[1] ; Pengfei,Wei ^[3] ; Zhilai,Yang ^[1] ; Lei,Zhang ^[1] ; Erwei,Gu ^[1] ; Guanghong,Xu ^[1] ; Chaozhao,Liang ^[2] ; Xuesheng,Liu ^[1]

作者单位： Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Hefei, China. ^[1] Department of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei, China. ^[2] School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China. ^[3]

关键词 Autophagy Cathepsin D Midazolam Mutant huntingtin protein (mHtt)Polyglutamine diseases

主题词动物(Animals);自噬(Autophagy);组织蛋白酶D(Cathepsin D);细胞存活(Cell Survival);微管相关蛋白质类(Microtubule-Associated Proteins);咪达唑仑(Midazolam);PC12细胞(PC12 Cells);大鼠(Rats);信号传导(Signal Transduction);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases)

DOI 10.1159/000491895

PMID 30025395

发布时间 2021-12-04

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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Cellular physiology and biochemistry

2018年48卷2期

683-691页

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