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HDAC2-dependent Antipsychotic-like Effects of Chronic Treatment with the HDAC Inhibitor SAHA in Mice.

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第一作者： Mario,de la Fuente Revenga

第一单位： Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, United States.

作者： Mario,de la Fuente Revenga ^[1] ; Daisuke,Ibi ^[2] ; Justin M,Saunders ^[1] ; Travis,Cuddy ^[1] ; Maryum K,Ijaz ^[1] ; Rudy,Toneatti ^[1] ; Mitsumasa,Kurita ^[3] ; Terrell,Holloway ^[3] ; Li,Shen ^[4] ; Jeremy,Seto ^[5] ; Mikhail G,Dozmorov ^[6] ; Javier,González-Maeso ^[7]

作者单位： Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, United States. ^[1] Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, United States; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Department of Chemical Pharmacology, Meijo University, Nagoya 468-8503, Japan. ^[2] Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States. ^[3] Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States. ^[4] Department of Biological Sciences, New York City College of Technology, Brooklyn, NY 11201, United States. ^[5] Department of Biostatistics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, United States. ^[6] Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, United States; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States. Electronic address: javier.maeso@vcuhealth.org. ^[7]

关键词 HDAC2 antipsychotics clozapine histone deacetylase (HDAC)schizophrenia vorinostat (SAHA)