Cabozantinib Exhibits Potent Antitumor Activity in Colorectal Cancer Patient-Derived Tumor Xenograft Models via Autophagy and Signaling Mechanisms.-论文-万方医学网

第一作者： Aaron J,Scott

第一单位： Division of Hematology and Oncology, Banner University of Arizona Cancer Center, Tucson, Arizona. ajscott@email.arizona.edu.

作者： Aaron J,Scott ^[1] ; John J,Arcaroli ^[2] ; Stacey M,Bagby ^[2] ; Rachel,Yahn ^[2] ; Kendra M,Huber ^[3] ; Natalie J,Serkova ^[3] ; Anna,Nguyen ^[2] ; Jihye,Kim ^[2] ; Andrew,Thorburn ^[4] ; Jon,Vogel ^[5] ; Kevin S,Quackenbush ^[2] ; Anna,Capasso ^[2] ; Anna,Schreiber ^[2] ; Patrick,Blatchford ^[2] ; Peter J,Klauck ^[2] ; Todd M,Pitts ^[2] ; S Gail,Eckhardt ^[6] ; Wells A,Messersmith ^[2]

作者单位： Division of Hematology and Oncology, Banner University of Arizona Cancer Center, Tucson, Arizona. ajscott@email.arizona.edu. ^[1] Division of Medical Oncology, University of Colorado Anschutz Medical Campus and University of Colorado Cancer Center, Aurora, Colorado. ^[2] Department of Anesthesia, University of Colorado Anschutz Medical Campus and University of Colorado Cancer Center, Aurora, Colorado. ^[3] Department of Pharmacology, University of Colorado Anschutz Medical Campus and University of Colorado Cancer Center, Aurora, Colorado. ^[4] Department of Surgery, University of Colorado Anschutz Medical Campus and University of Colorado Cancer Center, Aurora, Colorado. ^[5] Division of Medical Oncology, The University of Texas at Austin, Austin, Texas. ^[6]

医学主题词酰苯胺类(Anilides);动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);自噬(Autophagy);细胞系, 肿瘤(Cell Line, Tumor);结直肠肿瘤(Colorectal Neoplasms);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);人类(Humans);磁共振成像(Magnetic Resonance Imaging);小鼠(Mice);新生血管化, 病理性(Neovascularization, Pathologic);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);正电子发射断层显像术(Positron-Emission Tomography);蛋白激酶抑制剂(Protein Kinase Inhibitors);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);吡啶类(Pyridines);信号传导(Signal Transduction);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1158/1535-7163.MCT-17-0131

PMID 30026382

发布时间 2021-12-04

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Cabozantinib Exhibits Potent Antitumor Activity in Colorectal Cancer Patient-Derived Tumor Xenograft Models via Autophagy and Signaling Mechanisms.

Molecular cancer therapeutics

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Cabozantinib Exhibits Potent Antitumor Activity in Colorectal Cancer Patient-Derived Tumor Xenograft Models via Autophagy and Signaling Mechanisms.

Molecular cancer therapeutics

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同项目论文

Molecular cancer therapeutics

相关期刊

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