换一批Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
第一作者：
James J,Lee
第一单位：
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
作者：
James J,Lee [1]
;
Robbee,Wedow [2]
;
Aysu,Okbay [3]
;
Edward,Kong [4]
;
Omeed,Maghzian [4]
;
Meghan,Zacher [5]
;
Tuan Anh,Nguyen-Viet [6]
;
Peter,Bowers [4]
;
Julia,Sidorenko [7]
;
Richard,Karlsson Linnér [8]
;
Mark Alan,Fontana [9]
;
Tushar,Kundu [6]
;
Chanwook,Lee [4]
;
Hui,Li [4]
;
Ruoxi,Li [6]
;
Rebecca,Royer [6]
;
Pascal N,Timshel [10]
;
Raymond K,Walters [11]
;
Emily A,Willoughby [1]
;
Loïc,Yengo [12]
;
23andMe Research Team [13]
;
COGENT (Cognitive Genomics Consortium) [14]
;
Social Science Genetic Association Consortium [15]
;
Maris,Alver [16]
;
Yanchun,Bao [17]
;
David W,Clark [18]
;
Felix R,Day [12]
;
Nicholas A,Furlotte [17]
;
Peter K,Joshi [16]
;
Kathryn E,Kemper [13]
;
Aaron,Kleinman [19]
;
Claudia,Langenberg [20]
;
Reedik,Mägi [12]
;
Joey W,Trampush [21]
;
Shefali Setia,Verma [16]
;
Yang,Wu [22]
;
Max,Lam [2]
;
Jing Hua,Zhao [15]
;
Zhili,Zheng [23]
;
Jason D,Boardman [24]
;
Harry,Campbell [25]
;
Jeremy,Freese [26]
;
Kathleen Mullan,Harris [14]
;
Caroline,Hayward [27]
;
Pamela,Herd [16]
;
Meena,Kumari [27]
;
Todd,Lencz [28]
;
Jian'an,Luan [13]
;
Anil K,Malhotra [16]
;
Andres,Metspalu [16]
;
Lili,Milani [29]
;
Ken K,Ong [20]
;
John R B,Perry [15]
;
David J,Porteous [30]
;
Marylyn D,Ritchie [17]
;
Melissa C,Smart [16]
;
Blair H,Smith [31]
;
Joyce Y,Tung [32]
;
Nicholas J,Wareham [33]
;
James F,Wilson [13]
;
Jonathan P,Beauchamp [34]
;
Dalton C,Conley [35]
;
Tõnu,Esko [36]
;
Steven F,Lehrer [10]
;
Patrik K E,Magnusson [37]
;
Sven,Oskarsson [38]
;
Tune H,Pers [6]
;
Matthew R,Robinson [39]
;
Kevin,Thom [40]
;
Chelsea,Watson [4]
;
Christopher F,Chabris [41]
;
Michelle N,Meyer [42]
;
David I,Laibson [8]
;
Jian,Yang [11]
;
Magnus,Johannesson [43]
;
Philipp D,Koellinger [44]
;
Patrick,Turley [45]
;
Peter M,Visscher ;
Daniel J,Benjamin ;
David,Cesarini
作者单位：
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
[1]
Department of Sociology, University of Colorado Boulder, Boulder, CO, USA.;Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.;Institute of Behavioral Science, University of Colorado Boulder, Boulder, CO, USA.
[2]
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. a.okbay@vu.nl.;Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. a.okbay@vu.nl.
[3]
Department of Economics, Harvard University, Cambridge, MA, USA.
[4]
Department of Sociology, Harvard University, Cambridge, MA, USA.
[5]
Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.
[6]
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.;Estonian Genome Center, University of Tartu, Tartu, Estonia.
[7]
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.;Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.;Institute for Behavior and Biology, Erasmus University Rotterdam, Rotterdam, The Netherlands.
[8]
Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.;Center for the Advancement of Value in Musculoskeletal Care, Hospital for Special Surgery, New York, NY, USA.
[9]
The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.;Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark.
[10]
Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.;Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[11]
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
[12]
Estonian Genome Center, University of Tartu, Tartu, Estonia.
[13]
Institute for Social and Economic Research, University of Essex, Colchester, UK.
[14]
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
[15]
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
[16]
23andMe, Inc., Mountain View, CA, USA.
[17]
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.;Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland.
[18]
BrainWorkup, LLC, Santa Monica, CA, USA.;Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
[19]
Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA.
[20]
Institute of Mental Health, Singapore, Singapore.;Genome Institute, Singapore, Singapore.
[21]
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.;The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.
[22]
Department of Sociology, Stanford University, Stanford, CA, USA.
[23]
Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.;Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
[24]
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
[25]
Institute for Social and Economic Research, University of Essex, Colchester, UK.;La Follette School of Public Affairs, University of Wisconsin-Madison, Madison, WI, USA.
[26]
Departments of Psychiatry and Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, NY, USA.;Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USA.;Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, CA, USA.
[27]
Estonian Genome Center, University of Tartu, Tartu, Estonia.;Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
[28]
Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
[29]
Division of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.;Medical Research Institute, University of Dundee, Dundee, UK.
[30]
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.;MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
[31]
Department of Economics, University of Toronto, Toronto, Ontario, Canada.
[32]
Department of Sociology, Princeton University, Princeton, NJ, USA.
[33]
School of Policy Studies, Queen's University, Kingston, Ontario, Canada.;Department of Economics, New York University Shanghai, Pudong, Shanghai, China.;National Bureau of Economic Research, Cambridge, MA, USA.
[34]
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
[35]
Department of Government, Uppsala University, Uppsala, Sweden.
[36]
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.;Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
[37]
Department of Economics, New York University, New York, NY, USA.
[38]
Autism and Developmental Medicine Institute, Geisinger Health System, Lewisburg, PA, USA.
[39]
Center for Translational Bioethics and Health Care Policy, Geisinger Health System, Danville, PA, USA.
[40]
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.;Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
[41]
Department of Economics, Stockholm School of Economics, Stockholm, Sweden.
[42]
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. peter.visscher@uq.edu.au.;Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. peter.visscher@uq.edu.au.
[43]
Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA. daniel.benjamin@gmail.com.;National Bureau of Economic Research, Cambridge, MA, USA. daniel.benjamin@gmail.com.;Department of Economics, University of Southern California, Los Angeles, CA, USA. daniel.benjamin@gmail.com.
[44]
National Bureau of Economic Research, Cambridge, MA, USA.;Department of Economics, New York University, New York, NY, USA.;Center for Experimental Social Science, New York University, New York, NY, USA.
[45]
医学主题词
成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);队列研究(Cohort Studies);教育程度(Educational Status);女(雌)性(Female);全基因组关联研究(Genome-Wide Association Study);人类(Humans);男(雄)性(Male);中年人(Middle Aged);多因子遗传(Multifactorial Inheritance);表型(Phenotype);多态性, 单核苷酸(Polymorphism, Single Nucleotide)
DOI
10.1038/s41588-018-0147-3
PMID
30038396
发布时间
2025-05-30
- 浏览21
Nature genetics
Nature genetics
1112-1121页
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