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Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain.

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第一作者： Daniel,Felsky

第一单位： Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, 630 West 168th Street, PH 19 - 302, New York, NY, 10032, USA. df2652@columbia.edu.;Department of Neurology, Brigham and Woman's Hospital, 75 Francis Street, Boston, MA, 02115, USA. df2652@columbia.edu.;Department of Neurology, Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA. df2652@columbia.edu.;Program in Population and Medical Genetics, Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA, 02142, USA. df2652@columbia.edu.

作者： Daniel,Felsky ^[1] ; Ellis,Patrick ^[2] ; Julie A,Schneider ^[3] ; Sara,Mostafavi ^[4] ; Chris,Gaiteri ^[3] ; Nikolaos,Patsopoulos ^[5] ; David A,Bennett ^[3] ; Philip L,De Jager ^[6]

作者单位： Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, 630 West 168th Street, PH 19 - 302, New York, NY, 10032, USA. df2652@columbia.edu.;Department of Neurology, Brigham and Woman's Hospital, 75 Francis Street, Boston, MA, 02115, USA. df2652@columbia.edu.;Department of Neurology, Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA. df2652@columbia.edu.;Program in Population and Medical Genetics, Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA, 02142, USA. df2652@columbia.edu. ^[1] Department of Statistics, University of Sydney, Camperdown, NSW, 2006, Australia. ^[2] Department of Neurology, Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL, 60612, USA.;Rush Alzheimer's Disease Center, Rush University Medical Center, 600 South Paulina Street, Chicago, IL, 60612, USA. ^[3] Department of Statistics, University of British Columbia, 2329 West Mall, Vancouver, BC, V6T 1Z4, Canada. ^[4] Department of Neurology, Brigham and Woman's Hospital, 75 Francis Street, Boston, MA, 02115, USA.;Department of Neurology, Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA. ^[5] Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, 630 West 168th Street, PH 19 - 302, New York, NY, 10032, USA.;Department of Neurology, Brigham and Woman's Hospital, 75 Francis Street, Boston, MA, 02115, USA.;Department of Neurology, Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.;Program in Population and Medical Genetics, Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA, 02142, USA. ^[6]

关键词 Alzheimer’s disease Genomics Inflammation Innate immunity Microglia Neuropathology Polygenic score Postmortem RNA sequencing