Lung resident mesenchymal cells isolated from patients with the Bronchiolitis Obliterans Syndrome display a deregulated epigenetic profile.
第一作者:
Serena,Vella
第一单位:
Department of Laboratory Medicine and Advanced Biotechnologies, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Palermo, Italy. vellaserena@gmail.com.;Anemocyte S.r.l, Gerenzano, Italy. vellaserena@gmail.com.
作者:
医学主题词
成年人(Adult);老年人(Aged);闭塞性细支气管炎(Bronchiolitis Obliterans);支气管肺泡灌洗液(Bronchoalveolar Lavage Fluid);细胞分化(Cell Differentiation);细胞系(Cell Line);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);疾病恶化(Disease Progression);后成说, 遗传(Epigenesis, Genetic);女(雌)性(Female);纤维化(Fibrosis);移植物排斥(Graft Rejection);组蛋白密码(Histone Code);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);组蛋白脱乙酰基酶类(Histone Deacetylases);人类(Humans);肺(Lung);肺移植(Lung Transplantation);男(雄)性(Male);间质干细胞(Mesenchymal Stem Cells);微RNAs(MicroRNAs);中年人(Middle Aged);肌成纤维细胞(Myofibroblasts);转化生长因子β1(Transforming Growth Factor beta1)
DOI
10.1038/s41598-018-29504-5
PMID
30042393
发布时间
2024-03-28
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Scientific reports
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