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The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma.

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第一作者： Orsi,Giricz

第一单位： Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA.

作者： Orsi,Giricz ^[1] ; Yongkai,Mo ^[1] ; Kimberly B,Dahlman ^[2] ; Xiomaris M,Cotto-Rios ^[3] ; Chiara,Vardabasso ^[4] ; Hoa,Nguyen ^[5] ; Bernice,Matusow ^[5] ; Matthias,Bartenstein ^[1] ; Veronika,Polishchuk ^[1] ; Douglas B,Johnson ^[2] ; Tushar D,Bhagat ^[1] ; Rafe,Shellooe ^[5] ; Elizabeth,Burton ^[5] ; James,Tsai ^[5] ; Chao,Zhang ^[5] ; Gaston,Habets ^[5] ; John M,Greally ^[6] ; Yiting,Yu ^[1] ; Paraic A,Kenny ^[7] ; Gregg B,Fields ^[8] ; Kith,Pradhan ^[1] ; E Richard,Stanley ^[7] ; Emily,Bernstein ^[4] ; Gideon,Bollag ^[5] ; Evripidis,Gavathiotis ^[3] ; Brian L,West ^[5] ; Jeffrey A,Sosman ^[2] ; Amit K,Verma ^[1]

作者单位： Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA. ^[1] Vanderbilt University, Nashville, Tennessee, USA. ^[2] Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA. ^[3] Departments of Oncological Sciences & Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. ^[4] Plexxikon, Berkeley, California, USA. ^[5] Department of Genetics and. ^[6] Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA. ^[7] Department of Chemistry and Biochemistry, Florida Atlantic University, Florida, USA. ^[8]

关键词 Melanoma Oncology

医学主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);核心结合因子α2亚基(Core Binding Factor Alpha 2 Subunit);DNA甲基化(DNA Methylation);抗药性, 肿瘤(Drug Resistance, Neoplasm);药物协同作用(Drug Synergism);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);白细胞介素类(Interleukins);MAP激酶信号系统(MAP Kinase Signaling System);黑色素瘤(Melanoma);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);丝裂原激活蛋白激酶激酶类(Mitogen-Activated Protein Kinase Kinases);突变(Mutation);原癌基因蛋白质B-raf(Proto-Oncogene Proteins B-raf);受体, 粒细胞巨噬细胞集落刺激因子(Receptors, Granulocyte-Macrophage Colony-Stimulating Factor);移植, 异种(Transplantation, Heterologous);U937细胞(U937 Cells)

DOI 10.1172/jci.insight.120422

PMID 30046005

发布时间 2024-03-12

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The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma.

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The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma.

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