PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells.

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第一作者： Chaido,Stathopoulou

第一单位： Bio-Imaging Unit, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

作者： Chaido,Stathopoulou ^[1] ; Arunakumar,Gangaplara ^[2] ; Grace,Mallett ^[1] ; Francis A,Flomerfelt ^[3] ; Lukasz P,Liniany ^[1] ; David,Knight ^[4] ; Leigh A,Samsel ^[5] ; Rolando,Berlinguer-Palmini ^[1] ; Joshua J,Yim ^[6] ; Tania C,Felizardo ^[3] ; Michael A,Eckhaus ^[7] ; Laura,Edgington-Mitchell ^[8] ; Jonathan,Martinez-Fabregas ^[9] ; Jinfang,Zhu ^[2] ; Daniel H,Fowler ^[3] ; Sander I,van Kasteren ^[10] ; Arian,Laurence ^[11] ; Matthew,Bogyo ^[6] ; Colin,Watts ^[9] ; Ethan M,Shevach ^[2] ; Shoba,Amarnath ^[12]

作者单位： Bio-Imaging Unit, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. ^[1] Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. ^[2] Experimental Transplantation Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA. ^[3] Biological Mass Spectrometry Core, University of Manchester, Manchester M13 9PL, UK. ^[4] Flow Cytometry Core, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA. ^[5] School of Medicine, Stanford University, Stanford, CA 94305, USA. ^[6] Division of Veterinary Resources, Office of Research Services, NIH, Bethesda, MD 20892, USA. ^[7] School of Medicine, Stanford University, Stanford, CA 94305, USA; Drug Discovery Biology, Monash University, Melbourne, VIC 3800, Australia. ^[8] College of Life Sciences, University of Dundee, Dundee DD1 4HN, UK. ^[9] Leiden Institute of Chemistry and Institute of Chemical Immunology, Leiden University, 2311 EZ Leiden, the Netherlands. ^[10] Bio-Imaging Unit, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Translational Gastroenterology Unit, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, Headington, Oxford OX3 9DU, UK; Department of Haematology, Northern Centre for Cancer Care, Newcastle upon Tyne NE2 4HH, UK. ^[11] Bio-Imaging Unit, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Electronic address: shoba.amarnath@newcastle.ac.uk. ^[12]

关键词 AEP Foxp3 GvHD LCMV PD-1 PDL-1 colitis iTreg melanoma