20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats.

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第一作者： Lenka,Sedláková

第一单位： Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

作者： Lenka,Sedláková ^[1] ; Soňa,Kikerlová ^[1] ; Zuzana,Husková ^[1] ; Lenka,Červenková ^[1] ; Věra Čertíková,Chábová ^[1] ; Josef,Zicha ^[2] ; John R,Falck ^[3] ; John D,Imig ^[4] ; Elzbieta,Kompanowska-Jezierska ^[5] ; Janusz,Sadowski ^[6] ; Vojtěch,Krátký ^[6] ; Luděk,Červenka ^[1] ; Libor,Kopkan ^[7]

作者单位： Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. ^[1] Department of Nephrology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. ^[2] Institute of of Physiology, Czech Academy of Sciences, Prague, Czech Republic. ^[3] Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, U.S.A. ^[4] Department of Pharmacology and Toxicology, Medical College of Wisconsin, WI, U.S.A. ^[5] Department of Renal and Body Fluid Physiology, M. Mossakowski Medical Research Centre, Polish Academy of Science, Warsaw, Poland. ^[6] Department of Pathophysiology, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic. ^[7] Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic libor.kopkan@ikem.cz. ^[8]

关键词 20-hydroxyeicosatetraenoic acid cytochrome p450 metabolites malignant hypertension renin-angiotensin system