Safety and immunogenicity of Pfs25H-EPA/Alhydrogel, a transmission-blocking vaccine against Plasmodium falciparum: a randomised, double-blind, comparator-controlled, dose-escalation study in healthy Malian adults.

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作者： Issaka,Sagara ^[1] ; Sara A,Healy ^[2] ; Mahamadoun H,Assadou ^[1] ; Erin E,Gabriel ^[3] ; Mamady,Kone ^[1] ; Kourane,Sissoko ^[1] ; Intimbeye,Tembine ^[1] ; Merepen A,Guindo ^[1] ; M'Bouye,Doucoure ^[1] ; Karamoko,Niaré ^[1] ; Amagana,Dolo ^[1] ; Kelly M,Rausch ^[2] ; David L,Narum ^[2] ; David L,Jones ^[2] ; Nicholas J,MacDonald ^[2] ; Daming,Zhu ^[2] ; Rathy,Mohan ^[2] ; Olga,Muratova ^[2] ; Ibrahima,Baber ^[1] ; Mamadou B,Coulibaly ^[1] ; Michael P,Fay ^[4] ; Charles,Anderson ^[2] ; Yimin,Wu ^[2] ; Sekou F,Traore ^[1] ; Ogobara K,Doumbo ^[1] ; Patrick E,Duffy ^[5]

作者单位： Malaria Research and Training Center, Mali-National Institute of Allergy and Infectious Diseases International Center for Excellence in Research, University of Science, Techniques and Technologies of Bamako, Mali. ^[1] Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. ^[2] Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. ^[3] Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. ^[4] Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. Electronic address: patrick.duffy@nih.gov. ^[5]