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Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing <i>In Vitro</i> Susceptibility in Escherichia coli and Klebsiella pneumoniae.

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第一作者： Charles R,Dean

第一单位： Novartis Institutes for BioMedical Research, Emeryville, California, USA charlesr.dean@novartis.com.

作者： Charles R,Dean ^[1] ; David T,Barkan ^[2] ; Alun,Bermingham ^[2] ; Johanne,Blais ^[2] ; Fergal,Casey ^[2] ; Anthony,Casarez ^[2] ; Richard,Colvin ^[3] ; John,Fuller ^[2] ; Adriana K,Jones ^[2] ; Cindy,Li ^[2] ; Sara,Lopez ^[2] ; Louis E,Metzger ^[2] ; Mina,Mostafavi ^[2] ; Ramadevi,Prathapam ^[2] ; Dita,Rasper ^[2] ; Folkert,Reck ^[2] ; Alexey,Ruzin ^[2] ; Jacob,Shaul ^[2] ; Xiaoyu,Shen ^[2] ; Robert L,Simmons ^[2] ; Peter,Skewes-Cox ^[2] ; Kenneth T,Takeoka ^[2] ; Pramila,Tamrakar ^[2] ; Tsuyoshi,Uehara ^[2] ; Jun-Rong,Wei ^[2]

作者单位： Novartis Institutes for BioMedical Research, Emeryville, California, USA charlesr.dean@novartis.com. ^[1] Novartis Institutes for BioMedical Research, Emeryville, California, USA. ^[2] Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA. ^[3]

关键词 Enterobacteriaceae LYS228 beta-lactamases drug resistance mechanisms mechanisms of action monobactam