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E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function.

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第一作者： Tanis D,Godwin

第一单位： Cancer Genetics Laboratory, Centre for Translational Cancer Research (Te Aho Matatū), Department of Biochemistry, University of Otago, Dunedin, New Zealand.

作者： Tanis D,Godwin ^[1] ; S Thomas,Kelly ^[1] ; Tom P,Brew ^[1] ; Nicola M,Bougen-Zhukov ^[1] ; Andrew B,Single ^[1] ; Augustine,Chen ^[1] ; Cassie E,Stylianou ^[1] ; Lawrence D,Harris ^[2] ; Sophie K,Currie ^[1] ; Bryony J,Telford ^[1] ; Henry G,Beetham ^[1] ; Gary B,Evans ^[2] ; Michael A,Black ^[1] ; Parry J,Guilford ^[3]

作者单位： Cancer Genetics Laboratory, Centre for Translational Cancer Research (Te Aho Matatū), Department of Biochemistry, University of Otago, Dunedin, New Zealand. ^[1] The Ferrier Research Institute, Victoria University of Wellington, Wellington, New Zealand. ^[2] Cancer Genetics Laboratory, Centre for Translational Cancer Research (Te Aho Matatū), Department of Biochemistry, University of Otago, Dunedin, New Zealand. parry.guilford@otago.ac.nz.;Parry Guilford Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin, 9016, New Zealand. parry.guilford@otago.ac.nz. ^[3]

关键词 CDH1 Diffuse gastric cancer E-cadherin Plasma membrane Synthetic lethality