换一批
换一批Physiologically Based Pharmacokinetic Model of Itraconazole and Two of Its Metabolites to Improve the Predictions and the Mechanistic Understanding of CYP3A4 Drug-Drug Interactions.
第一作者：
Luna,Prieto Garcia
第一单位：
Drug Metabolism and Pharmacokinetics; Cardiovascular, Renal and Metabolism (L.P.G., D.J., K.P.K., A.L.) and Quantitative Clinical Pharmacology; Early Clinical Development (H.E.), IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden; and Department of Pharmacy, Uppsala University, Uppsala, Sweden (H.L.) luna.prietogarcia@astrazeneca.com.
作者：
主题词
动物(Animals);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);药物相互作用(Drug Interactions);人类(Humans);伊曲康唑(Itraconazole);男(雄)性(Male);咪达唑仑(Midazolam);蛋白质结合(Protein Binding);大鼠(Rats);大鼠, Wistar(Rats, Wistar)
DOI
10.1124/dmd.118.081364
PMID
30068519
发布时间
2025-02-12
- 浏览12
Drug metabolism and disposition
1420-1433页
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