SUMO-mediated regulation of NLRP3 modulates inflammasome activity.

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作者： Rachael,Barry ^[1] ; Sidonie Wicky,John ^[2] ; Gianmaria,Liccardi ^[2] ; Tencho,Tenev ^[2] ; Isabel,Jaco ^[2] ; Chih-Hong,Chen ^[3] ; Justin,Choi ^[3] ; Paulina,Kasperkiewicz ^[4] ; Teresa,Fernandes-Alnemri ^[5] ; Emad,Alnemri ^[5] ; Marcin,Drag ^[4] ; Yuan,Chen ^[3] ; Pascal,Meier ^[6]

作者单位： The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK.;MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK. ^[1] The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK. ^[2] Department of Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, California, 91010, USA. ^[3] Division of Bioorganic Chemistry, Department of Chemistry, Wroclaw University of Technology, Wyb. Wyspianskiego 27, 50-370, Wroclaw, Poland. ^[4] Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, 19107, PA, USA. ^[5] The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK. pmeier@icr.ac.uk. ^[6]