Quantitation of Human Whole-Body Synthesis-Secretion Rates of Docosahexaenoic Acid and Eicosapentaenoate Acid from Circulating Unesterified α-Linolenic Acid at Steady State.

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作者： Yu-Hong,Lin ^[1] ; Joseph R,Hibbeln ^[1] ; Anthony F,Domenichiello ^[2] ; Christopher E,Ramsden ^[3] ; Nicholas M,Salem ^[1] ; Chuck T,Chen ^[1] ; Haksong,Jin ^[4] ; Amber B,Courville ^[5] ; Sharon F,Majchrzak-Hong ^[1] ; Stanley I,Rapoport ^[1] ; Richard P,Bazinet ^[6] ; Bernard V,Miller ^[7]

作者单位： Section of Nutritional Neuroscience, LMBB, DICBR, NIAAA, NIH, 5625 Fishers Lane Rm 3N07, Bethesda, MD, 20892, USA. ^[1] Lipid Mediators of Inflammation and Pain Unit, Laboratory of Clinical Investigation, NIA, NIH, Baltimore, MD, 21224, USA. ^[2] Lipid Mediators of Inflammation and Pain Unit, Laboratory of Clinical Investigation, NIA, NIH, Baltimore, MD, 21224, USA.;DICBR, NIAAA, NIH, Bethesda, MD, 20892, USA.;School of Agriculture, Food and Wine, University of Adelaide, Adelaide, SA, Australia. ^[3] Pharmacy Department, NIH Clinical Center, NIH, Bethesda, MD, 20892, USA. ^[4] Nutrition Department, NIH Clinical Center, NIH, Bethesda, MD, 20892, USA. ^[5] Department of Nutritional Science, University of Toronto, Toronto, ON, M5S 3E2, Canada. ^[6] NIDDK, NIH, Bethesda, MD, 20892, USA. ^[7]

关键词 Hepatic synthesis-secretion Kinetics Low-linoleate diet Mass spectrometry Tetracosahexaenoic acid