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Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle.

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第一作者： Richard L,Mackman

第一单位： Gilead Sciences Inc. , 333 Lakeside Drive , Foster City , California 94404 , United States.

作者： Richard L,Mackman ^[1] ; Victoria A,Steadman ^[2] ; David K,Dean ^[2] ; Petr,Jansa ^[1] ; Karine G,Poullennec ^[2] ; Todd,Appleby ^[1] ; Carol,Austin ^[2] ; Caroline A,Blakemore ^[2] ; Ruby,Cai ^[1] ; Carina,Cannizzaro ^[1] ; Gregory,Chin ^[1] ; Jean-Yves C,Chiva ^[2] ; Neil A,Dunbar ^[2] ; Hans,Fliri ^[3] ; Adrian J,Highton ^[2] ; Hon,Hui ^[1] ; Mingzhe,Ji ^[1] ; Haolun,Jin ^[1] ; Kapil,Karki ^[1] ; Andrew J,Keats ^[2] ; Linos,Lazarides ^[2] ; Yu-Jen,Lee ^[1] ; Albert,Liclican ^[1] ; Michael,Mish ^[1] ; Bernard,Murray ^[1] ; Simon B,Pettit ^[2] ; Peter,Pyun ^[1] ; Michael,Sangi ^[1] ; Rex,Santos ^[1] ; Jonathan,Sanvoisin ^[2] ; Uli,Schmitz ^[1] ; Adam,Schrier ^[1] ; Dustin,Siegel ^[1] ; David,Sperandio ^[1] ; George,Stepan ^[1] ; Yang,Tian ^[1] ; Gregory M,Watt ^[2] ; Hai,Yang ^[1] ; Brian E,Schultz ^[1]

作者单位： Gilead Sciences Inc. , 333 Lakeside Drive , Foster City , California 94404 , United States. ^[1] Selcia Ltd. , Fyfield Business and Research Park, Fyfield Road , Ongar , Essex CM5 0GS , United Kingdom. ^[2] Cypralis Ltd. , Babraham Research Campus, Cambridge CB22 3AT , United Kingdom. ^[3]