PCBP1 depletion promotes tumorigenesis through attenuation of p27<sup>Kip1</sup> mRNA stability and translation.
第一作者:
Hongshun,Shi
第一单位:
Centre for Translational Medicine, the First Affiliated Hospital, SUN Yat-sen University, 58 Second Zhongshan Road, Guangzhou, 510080, China.;Department of Biochemistry, Zhongshan School of Medicine, SUN Yat-sen University, 74 Second Zhongshan Road, Guangzhou, 510080, China.
作者:
主题词
3'非翻译区(3' Untranslated Regions);动物(Animals);细胞凋亡(Apoptosis);乳腺肿瘤(Breast Neoplasms);细胞周期(Cell Cycle);细胞系, 肿瘤(Cell Line, Tumor);周期素依赖激酶抑制剂p27(Cyclin-Dependent Kinase Inhibitor p27);DNA结合蛋白质类(DNA-Binding Proteins);女(雌)性(Female);核不均一核糖核蛋白类(Heterogeneous-Nuclear Ribonucleoproteins);人类(Humans);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);卵巢肿瘤(Ovarian Neoplasms);磷酰化(Phosphorylation);蛋白质生物合成(Protein Biosynthesis);RNA稳定性(RNA Stability);RNA, 信使(RNA, Messenger);RNA结合蛋白质类(RNA-Binding Proteins);增量调节(Up-Regulation)
DOI
10.1186/s13046-018-0840-1
PMID
30086790
发布时间
2020-12-09
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