EGFR gene copy number decreases during anti-EGFR antibody therapy in colorectal cancer.-论文-万方医学网

第一作者： Eva-Maria,Birkman

第一单位： Department of Pathology, University of Turku, 20520 Turku, Finland; Department of Pathology, Turku University Hospital, 20520 Turku, Finland. Electronic address: emabir@utu.fi.

作者： Eva-Maria,Birkman ^[1] ; Tuulia,Avoranta ^[2] ; Annika,Ålgars ^[3] ; Eija,Korkeila ^[4] ; Minnamaija,Lintunen ^[5] ; Laura,Lahtinen ^[6] ; Teijo,Kuopio ^[7] ; Raija,Ristamäki ^[4] ; Olli,Carpén ^[8] ; Jari,Sundström ^[9]

作者单位： Department of Pathology, University of Turku, 20520 Turku, Finland; Department of Pathology, Turku University Hospital, 20520 Turku, Finland. Electronic address: emabir@utu.fi. ^[1] Department of Pathology, University of Turku, 20520 Turku, Finland; Department of Oncology, Turku University Hospital, 20521 Turku, Finland. ^[2] Department of Oncology, Turku University Hospital, 20521 Turku, Finland; MediCity Research Laboratory, University of Turku, 20520 Turku, Finland. ^[3] Department of Oncology, Turku University Hospital, 20521 Turku, Finland. ^[4] Department of Pathology, Turku University Hospital, 20520 Turku, Finland. ^[5] Department of Pathology, Central Finland Central Hospital, 40620 Jyväskylä, Finland. ^[6] Department of Pathology, Central Finland Central Hospital, 40620 Jyväskylä, Finland; Department of Biological and Environmental Science, University of Jyväskylä, 40014 Jyväskylä, Finland. ^[7] Pathology, Research Programs Unit and HUSLAB, University of Helsinki and Helsinki University Hospital, 00014 Helsinki, Finland; Auria Biobank, University of Turku and Turku University Hospital, 20521 Turku, Finland. ^[8] Department of Pathology, University of Turku, 20520 Turku, Finland; Department of Pathology, Turku University Hospital, 20520 Turku, Finland. ^[9]

主题词腺癌(Adenocarcinoma);成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);化学疗法, 辅助(Chemotherapy, Adjuvant);结直肠肿瘤(Colorectal Neoplasms);减量调节(Down-Regulation);女(雌)性(Female);基因剂量(Gene Dosage);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);免疫组织化学(Immunohistochemistry);原位杂交, 荧光(In Situ Hybridization, Fluorescence);男(雄)性(Male);中年人(Middle Aged);突变(Mutation);肿瘤复发, 局部(Neoplasm Recurrence, Local);原癌基因蛋白质类p21(ras)(Proto-Oncogene Proteins p21(ras));回顾性研究(Retrospective Studies);时间因素(Time Factors);治疗结果(Treatment Outcome)

DOI 10.1016/j.humpath.2018.07.028

PMID 30096327

发布时间 2019-10-22

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EGFR gene copy number decreases during anti-EGFR antibody therapy in colorectal cancer.

Human pathology

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Human pathology

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EGFR gene copy number decreases during anti-EGFR antibody therapy in colorectal cancer.

Human pathology

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Human pathology

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