Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization.

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第一作者： Matteo,Bianchi

第一单位： Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.

作者： Matteo,Bianchi ^[1] ; Hannah L,Turner ^[2] ; Bartek,Nogal ^[2] ; Christopher A,Cottrell ^[2] ; David,Oyen ^[2] ; Matthias,Pauthner ^[1] ; Raiza,Bastidas ^[1] ; Rebecca,Nedellec ^[1] ; Laura E,McCoy ^[3] ; Ian A,Wilson ^[4] ; Dennis R,Burton ^[5] ; Andrew B,Ward ^[6] ; Lars,Hangartner ^[7]

作者单位： Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA. ^[1] Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. ^[2] Division of Infection and Immunity, University College London, London WC1E 6BT, UK. ^[3] Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. ^[4] Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA. ^[5] Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: andrew@scripps.edu. ^[6] Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: lhangart@scripps.edu. ^[7]

关键词 BG505 Env HIV SOSIP antibodies antibody epitope mapping cryo-EM electron microscopy negative-stain EM polyclonal antibodies vaccine