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首页> Structure (London, England : 1993)> Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain.

Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain.

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作者： Ryan P,Emptage ^[1] ; Mark A,Lemmon ^[2] ; Kathryn M,Ferguson ^[2] ; Ronen,Marmorstein ^[3]

作者单位： Department of Biochemistry and Biophysics and the Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: emptage@upenn.edu. ^[1] Department of Pharmacology and Cancer Biology Institute, Yale University School of Medicine, New Haven, CT 06520, USA. ^[2] Department of Biochemistry and Biophysics and the Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: marmor@upenn.edu. ^[3]

关键词 C-terminal domain MARK1 Tau protein activation segment autoinhibition inhibitory mechanism serine/threonine protein kinase structural biology αD helix

主题词结合部位(Binding Sites);克隆, 分子(Cloning, Molecular);结晶学, X线(Crystallography, X-Ray);大肠杆菌(Escherichia coli);基因表达(Gene Expression);遗传载体(Genetic Vectors);人类(Humans);动力学(Kinetics);模型, 分子(Models, Molecular);突变(Mutation);肽类(Peptides);蛋白质结合(Protein Binding);蛋白质相互作用域和基序(Protein Interaction Domains and Motifs);重组蛋白质类(Recombinant Proteins);结构同源性, 蛋白质(Structural Homology, Protein);底物特异性(Substrate Specificity);热力学(Thermodynamics)

DOI 10.1016/j.str.2018.05.008

PMID 30099988

发布时间 2021-12-04

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Structure (London, England : 1993)

Structure (London, England

2018年26卷8期

1137-1143.e3页

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