Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia.

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第一作者： Marlies,Vanden Bempt

第一单位： KU Leuven Center for Human Genetics, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology, VIB, Leuven, Belgium.

作者： Marlies,Vanden Bempt ^[1] ; Sofie,Demeyer ^[1] ; Michaël,Broux ^[1] ; Jolien,De Bie ^[1] ; Simon,Bornschein ^[1] ; Nicole,Mentens ^[1] ; Roel,Vandepoel ^[1] ; Ellen,Geerdens ^[1] ; Enrico,Radaelli ^[2] ; Beat C,Bornhauser ^[3] ; Andreas E,Kulozik ^[4] ; Jules P,Meijerink ^[5] ; Jean-Pierre,Bourquin ^[3] ; Charles E,de Bock ^[6] ; Jan,Cools ^[7]

作者单位： KU Leuven Center for Human Genetics, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology, VIB, Leuven, Belgium. ^[1] KU Leuven Center for Human Genetics, KU Leuven, Leuven, Belgium. ^[2] Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland. ^[3] Department of Pediatric Hematology and Oncology, Heidelberg University Children's Hospital, Heidelberg, Germany; Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germany. ^[4] Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands. ^[5] KU Leuven Center for Human Genetics, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology, VIB, Leuven, Belgium. Electronic address: charles.debock@kuleuven.vib.be. ^[6] KU Leuven Center for Human Genetics, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology, VIB, Leuven, Belgium. Electronic address: jan.cools@kuleuven.vib.be. ^[7]

关键词 cancer cooperation leukemia mouse model oncogenes signaling transcriptional regulation