Synthesis and growth-inhibitory activities of imidazo[5,1-<i>d</i>]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position.

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作者： David,Cousin ^[1] ; Marc G,Hummersone ^[1] ; Tracey D,Bradshaw ^[2] ; Jihong,Zhang ^[2] ; Christopher J,Moody ^[3] ; Magdalena B,Foreiter ^[3] ; Helen S,Summers ^[3] ; William,Lewis ^[3] ; Richard T,Wheelhouse ^[4] ; Malcolm F G,Stevens ^[2]

作者单位： Pharminox Ltd , Biocity , Pennyfoot St. , Nottingham NG1 1GF , UK. ^[1] School of Pharmacy , University of Nottingham , NG7 2RD , UK . Email: tracey.bradshaw@nottingham.ac.uk ; Email: malcolm.stevens@nottingham.ac.uk. ^[2] School of Chemistry , University of Nottingham , NG7 2RD , UK . Email: c.j.moody@nottingham.ac.uk. ^[3] Institute of Cancer Therapeutics , School of Pharmacy and Medical Sciences , University of Bradford , Bradford , BD7 1DP , UK. ^[4]

DOI 10.1039/c7md00554g

PMID 30108945

发布时间 2022-02-16

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MedChemComm

2018年9卷3期

545-553页

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Synthesis and growth-inhibitory activities of imidazo[5,1-<i>d</i>]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position.

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Synthesis and growth-inhibitory activities of imidazo[5,1-<i>d</i>]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position.

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