Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.-论文-万方医学网

第一作者： Thu Lan,Nguyen

第一单位： Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Translational Medicine and Neurogenetics, 67400 Illkirch, France.

作者： Thu Lan,Nguyen ^[1] ; Arnaud,Duchon ^[2] ; Antigoni,Manousopoulou ^[3] ; Nadège,Loaëc ^[4] ; Benoît,Villiers ^[5] ; Guillaume,Pani ^[1] ; Meltem,Karatas ^[2] ; Anna E,Mechling ^[3] ; Laura-Adela,Harsan ^[4] ; Emmanuelle,Limanton ^[6] ; Jean-Pierre,Bazureau ^[5] ; François,Carreaux ^[5] ; Spiros D,Garbis ^[1] ; Laurent,Meijer ^[2] ; Yann,Herault ^[3]

作者单位： Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Translational Medicine and Neurogenetics, 67400 Illkirch, France. ^[1] Centre National de la Recherche Scientifique, UMR7104, 67400 Illkirch, France. ^[2] Institut National de la Santé et de la Recherche Médicale, U964, 67400 Illkirch, France. ^[3] Université de Strasbourg, 67400 Illkirch, France. ^[4] ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, Bretagne, France. ^[5] Faculty of Medicine/Cancer Sciences & Clinical and Experimental Medicine, University of Southampton, Center for Proteomic Research, Life Sciences Building 85, Highfield, Southampton SO17 1BJ, UK. ^[6] Laboratory of Engineering, Informatics and Imaging (ICube), Integrative multimodal imaging in healthcare (IMIS), UMR 7357, and University Hospital Strasbourg, Department of Biophysics and Nuclear Medicine, University of Strasbourg, 67400 Illkirch, France. ^[7] Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Breisacher Strasse 60a, 79106 Freiburg, Germany. ^[8] Université de Rennes 1, ISCR (Institut des sciences chimiques de Rennes)-UMR, 6226, 35000 Rennes, France. ^[9] Faculty of Medicine/Cancer Sciences & Clinical and Experimental Medicine, University of Southampton, Center for Proteomic Research, Life Sciences Building 85, Highfield, Southampton SO17 1BJ, UK sgarbis@caltech.edu meijer@manros-therapeutics.com herault@igbmc.fr. ^[10] ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, Bretagne, France sgarbis@caltech.edu meijer@manros-therapeutics.com herault@igbmc.fr. ^[11] Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Translational Medicine and Neurogenetics, 67400 Illkirch, France sgarbis@caltech.edu meijer@manros-therapeutics.com herault@igbmc.fr. ^[12]

主题词氨基酸序列(Amino Acid Sequence);动物(Animals);生物催化(Biocatalysis);脑(Brain);细胞质(Cytoplasm);细胞骨架(Cytoskeleton);二恶茂类(Dioxoles);疾病模型, 动物(Disease Models, Animal);唐氏综合征(Down Syndrome);咪唑类(Imidazoles);磁共振成像(Magnetic Resonance Imaging);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交C57BL(Mice, Inbred C57BL);神经网(Nerve Net);磷酰化(Phosphorylation);蛋白质结合(Protein Binding);蛋白激酶抑制剂(Protein Kinase Inhibitors);蛋白酪氨酸激酶类(Protein-Tyrosine Kinases);蛋白质组学(Proteomics);RNA, 信使(RNA, Messenger);突触(Synapses);突触蛋白类(Synapsins)

DOI 10.1242/dmm.035634

PMID 30115750

发布时间 2023-12-13

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Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.

Disease models & mechanisms

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Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.

Disease models & mechanisms

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Disease models & mechanisms

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