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The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila.

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第一作者： Akira,Goto

第一单位： Université de Strasbourg, CNRS, Insect Models of Innate Immunity (M3I; UPR9022), 67084 Strasbourg, France; Sino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China. Electronic address: goto@unistra.fr.

作者： Akira,Goto ^[1] ; Kiyoshi,Okado ^[2] ; Nelson,Martins ^[3] ; Hua,Cai ^[3] ; Vincent,Barbier ^[2] ; Olivier,Lamiable ^[2] ; Laurent,Troxler ^[2] ; Estelle,Santiago ^[2] ; Lauriane,Kuhn ^[4] ; Donggi,Paik ^[5] ; Neal,Silverman ^[5] ; Andreas,Holleufer ^[6] ; Rune,Hartmann ^[6] ; Jiyong,Liu ^[7] ; Tao,Peng ^[7] ; Jules A,Hoffmann ^[8] ; Carine,Meignin ^[2] ; Laurent,Daeffler ^[2] ; Jean-Luc,Imler ^[9]

作者单位： Université de Strasbourg, CNRS, Insect Models of Innate Immunity (M3I; UPR9022), 67084 Strasbourg, France; Sino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China. Electronic address: goto@unistra.fr. ^[1] Université de Strasbourg, CNRS, Insect Models of Innate Immunity (M3I; UPR9022), 67084 Strasbourg, France. ^[2] Université de Strasbourg, CNRS, Insect Models of Innate Immunity (M3I; UPR9022), 67084 Strasbourg, France; Sino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China. ^[3] Université de Strasbourg, CNRS, Plateforme Protéomique Strasbourg-Esplanade, 67000 Strasbourg, France. ^[4] Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. ^[5] Center for Structural Biology, Aarhus University, 8000 Aarhus C, Denmark. ^[6] Sino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China. ^[7] Université de Strasbourg, CNRS, Insect Models of Innate Immunity (M3I; UPR9022), 67084 Strasbourg, France; Sino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China; University of Strasbourg Institute for Advanced Study, 67000 Strasbourg, France. ^[8] Université de Strasbourg, CNRS, Insect Models of Innate Immunity (M3I; UPR9022), 67084 Strasbourg, France; Sino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China. Electronic address: jl.imler@unistra.fr. ^[9]

关键词 C19orf12 Dicistrovirus Drosophila melanogaster IKKβ IMD pathway NF-κB STING antiviral immunity innate immunity picornavirus