换一批
换一批A minimal physiologically based pharmacokinetic model to investigate FcRn-mediated monoclonal antibody salvage: Effects of K<sub>on</sub>, K<sub>off</sub>, endosome trafficking, and animal species.
第一作者：
Brian M,Maas
第一单位：
a Division of Pharmacotherapy and Experimental Therapeutics , UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill , USA.
作者：
主题词
算法(Algorithms);动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);抗体亲和力(Antibody Affinity);生物转运(Biological Transport);内颗粒(Endosomes);组织相容性抗原Ⅰ类(Histocompatibility Antigens Class I);人类(Humans);氢离子浓度(Hydrogen-Ion Concentration);动力学(Kinetics);代谢清除率(Metabolic Clearance Rate);模型, 生物学(Models, Biological);蛋白质结合(Protein Binding);受体, Fc(Receptors, Fc);种特异性(Species Specificity)
DOI
10.1080/19420862.2018.1506648
PMID
30130450
发布时间
2019-10-08
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mAbs
1322-1331页
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