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Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system.

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第一作者： Carlota,Oleaga

第一单位： NanoScience Technology Center, University of Central Florida, 12424 Research Parkway Suite 400, Orlando, FL 32826, USA.

作者： Carlota,Oleaga ^[1] ; Anne,Riu ^[2] ; Sandra,Rothemund ^[1] ; Andrea,Lavado ^[1] ; Christopher W,McAleer ^[3] ; Christopher J,Long ^[3] ; Keisha,Persaud ^[1] ; Narasimhan Sriram,Narasimhan ^[4] ; My,Tran ^[4] ; Jeffry,Roles ^[1] ; Carlos A,Carmona-Moran ^[1] ; Trevor,Sasserath ^[4] ; Daniel H,Elbrecht ^[3] ; Lee,Kumanchik ^[1] ; L Richard,Bridges ^[4] ; Candace,Martin ^[1] ; Mark T,Schnepper ^[1] ; Gail,Ekman ^[1] ; Max,Jackson ^[1] ; Ying I,Wang ^[5] ; Reine,Note ^[2] ; Jessica,Langer ^[6] ; Silvia,Teissier ^[2] ; James J,Hickman ^[7]

作者单位： NanoScience Technology Center, University of Central Florida, 12424 Research Parkway Suite 400, Orlando, FL 32826, USA. ^[1] L'Oreal Research, and Innovation Division, Aulnay-sous-Bois, France. ^[2] NanoScience Technology Center, University of Central Florida, 12424 Research Parkway Suite 400, Orlando, FL 32826, USA; Hesperos, Inc., 3259 Progress Dr, Room 158, Orlando, FL 32826, USA. ^[3] Hesperos, Inc., 3259 Progress Dr, Room 158, Orlando, FL 32826, USA. ^[4] NanoScience Technology Center, University of Central Florida, 12424 Research Parkway Suite 400, Orlando, FL 32826, USA; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA. ^[5] L'Oreal Research, and Innovation Division, Clark, NJ, USA. ^[6] NanoScience Technology Center, University of Central Florida, 12424 Research Parkway Suite 400, Orlando, FL 32826, USA. Electronic address: jhickman@ucf.edu. ^[7]

关键词 Cardiotoxicity Functional readouts Human-on-a-chip Metabolism Non-invasive