Epigenetic Reprogramming with Antisense Oligonucleotides Enhances the Effectiveness of Androgen Receptor Inhibition in Castration-Resistant Prostate Cancer.-论文-万方医学网

作者： Lanbo,Xiao ^[1] ; Jean C,Tien ^[2] ; Josh,Vo ^[1] ; Mengyao,Tan ^[2] ; Abhijit,Parolia ^[1] ; Yajia,Zhang ^[3] ; Lisha,Wang ^[1] ; Yuanyuan,Qiao ^[2] ; Sudhanshu,Shukla ^[1] ; Xiaoju,Wang ^[2] ; Heng,Zheng ^[1] ; Fengyun,Su ^[2] ; Xiaojun,Jing ^[1] ; Esther,Luo ^[2] ; Andrew,Delekta ^[1] ; Kristin M,Juckette ^[2] ; Alice,Xu ^[1] ; Xuhong,Cao ^[2] ; Ajjai S,Alva ^[4] ; Youngsoo,Kim ^[1] ; A Robert,MacLeod ^[2] ; Arul M,Chinnaiyan ^[1]

作者单位： Michigan Center for Translational Pathology, Ann Arbor, Michigan. ^[1] Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan. ^[2] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan. ^[3] Department of Biosciences and Bioengineering, Indian Institute of Technology Dharwad, Dharwad, Karnataka, India. ^[4] Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan. ^[5] Ionis Pharmaceuticals, Carlsbad, California. ^[6] Michigan Center for Translational Pathology, Ann Arbor, Michigan. arul@umich.edu. ^[7] Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan. ^[8]

主题词雄激素拮抗药(Androgen Antagonists);雄激素受体拮抗剂(Androgen Receptor Antagonists);雄甾烯类(Androstenes);动物(Animals);苯甲酰胺类(Benzamides);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);疾病恶化(Disease Progression);抗药性, 肿瘤(Drug Resistance, Neoplasm);后成说, 遗传(Epigenesis, Genetic);人类(Humans);男(雄)性(Male);小鼠(Mice);小鼠, SCID(Mice, SCID);肿瘤复发, 局部(Neoplasm Recurrence, Local);肿瘤移植(Neoplasm Transplantation);腈类(Nitriles);寡核苷酸类, 反义(Oligonucleotides, Antisense);苯硫乙内酰脲(Phenylthiohydantoin);预后(Prognosis);受体, 雄激素(Receptors, Androgen);信号传导(Signal Transduction)

DOI 10.1158/0008-5472.CAN-18-0941

PMID 30135193

发布时间 2022-01-29

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Epigenetic Reprogramming with Antisense Oligonucleotides Enhances the Effectiveness of Androgen Receptor Inhibition in Castration-Resistant Prostate Cancer.

Cancer research

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Cancer research

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Epigenetic Reprogramming with Antisense Oligonucleotides Enhances the Effectiveness of Androgen Receptor Inhibition in Castration-Resistant Prostate Cancer.

Cancer research

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Cancer research

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