The combination of epigenetic drugs SAHA and HCI-2509 synergistically inhibits EWS-FLI1 and tumor growth in Ewing sarcoma.

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作者： Daniel Jose,García-Domínguez ^[1] ; Lourdes,Hontecillas-Prieto ^[1] ; Pablo,Rodríguez-Núñez ^[1] ; Guillem,Pascual-Pasto ^[2] ; Monica,Vila-Ubach ^[2] ; Rosa,García-Mejías ^[1] ; María José,Robles ^[1] ; Oscar M,Tirado ^[3] ; Jaume,Mora ^[4] ; Angel M,Carcaboso ^[2] ; Enrique,de Álava ^[2]

作者单位： Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla/CIBERONC, Seville, Spain. ^[1] Developmental Tumour Biology Laboratory, Hospital Sant Joan de Déu, Barcelona, Spain. ^[2] Pathology Unit, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla/CIBERONC, Seville, Spain. ^[3] Sarcoma Research Group, Laboratori d'Oncología Molecular, Institut d'Investigació Biomédica de Bellvitge (IDIBELL)/CIBERONC, L'Hospitalet de Llobregat, Barcelona, Spain. ^[4]

关键词 EWSR1 Ewing sarcoma PDX epigenetic drug synergism effect

DOI 10.18632/oncotarget.25829

PMID 30140378

发布时间 2022-03-22

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