IL-11 antagonist suppresses Th17 cell-mediated neuroinflammation and demyelination in a mouse model of relapsing-remitting multiple sclerosis.

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作者： Xin,Zhang ^[1] ; Nazanin,Kiapour ^[2] ; Sahil,Kapoor ^[2] ; Joseph R,Merrill ^[3] ; Yongjuan,Xia ^[4] ; Woomi,Ban ^[3] ; Stephanie M,Cohen ^[4] ; Bentley R,Midkiff ^[4] ; Valerie,Jewells ^[5] ; Yen-Yu I,Shih ^[6] ; Silva,Markovic-Plese ^[7]

作者单位： Department of Neurology, University of North Carolina at Chapel Hill, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA. Electronic address: xin.zhang193@duke.edu. ^[1] Department of Neurology, University of North Carolina at Chapel Hill, USA. ^[2] Biomedical Research Imaging Center, University of North Carolina, USA. ^[3] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA. ^[4] Department of Radiology, University of North Carolina at Chapel Hill, USA. ^[5] Department of Neurology, University of North Carolina at Chapel Hill, USA; Biomedical Research Imaging Center, University of North Carolina, USA. ^[6] Department of Neurology, University of North Carolina at Chapel Hill, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, USA. ^[7]

关键词 Demyelination Diffusion Tensor Imaging Experimental autoimmune encephalomyelitis IL-11 Multiple sclerosis Th17 cells