Self-emulsifying drug delivery systems changing their zeta potential via a flip-flop mechanism.

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作者： Esmaeil,Salimi ^[1] ; Bao,Le-Vinh ^[2] ; Forouhe,Zahir-Jouzdani ^[3] ; Barbara,Matuszczak ^[4] ; Azadeh,Ghaee ^[5] ; Andreas,Bernkop-Schnürch ^[6]

作者单位： Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, P. O. Box: 143951374, Tehran, Iran; Faculty of Chemical and Materials Engineering, Shahrood University of Technology, P. O. Box: 3619995161, Shahrood, Iran. ^[1] Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, A-6020 Innsbruck, Austria; Department of Industrial Pharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam. ^[2] Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, A-6020 Innsbruck, Austria; Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14174, Iran. ^[3] Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, A-6020 Innsbruck, Austria. ^[4] Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, P. O. Box: 143951374, Tehran, Iran. ^[5] Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, A-6020 Innsbruck, Austria. Electronic address: andreas.bernkop@uibk.ac.at. ^[6]

关键词 Intestinal alkaline phosphatase Mucus barrier Self-emulsifying drug delivery systems Zeta potential changing systems

主题词 Caco-2细胞(Caco-2 Cells);化学, 药物(Chemistry, Pharmaceutical);药物释放系统(Drug Delivery Systems);乳化剂(Emulsifying Agents);乳状剂(Emulsions);人类(Humans);纳米粒子(Nanoparticles)

DOI 10.1016/j.ijpharm.2018.08.046

PMID 30149127

发布时间 2019-08-19

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