Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot auto-inhibition and activation.

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作者： Duxiao,Yang ^[1] ; Peng,Xiao ^[1] ; Qing,Li ^[2] ; Xiaolei,Fu ^[3] ; Chang,Pan ^[1] ; Di,Lu ^[1] ; Shishuai,Wen ^[1] ; Wanying,Xia ^[2] ; Dongfang,He ^[1] ; Hui,Li ^[1] ; Hao,Fang ^[3] ; Yuemao,Shen ^[2] ; Zhigang,Xu ^[2] ; Amy,Lin ^[4] ; Chuan,Wang ^[5] ; Xiao,Yu ^[6] ; Jiawei,Wu ^[3] ; Jinpeng,Sun ^[7]

作者单位： From the Key Laboratory Experimental Teratology of the Ministry of Education, Department of Biochemistry and Molecular Biology, and. ^[1] the School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250012, China. ^[2] the Department of Physiology, Shandong University School of Medicine, Jinan, Shandong 250012, China. ^[3] the School of Life Science, Shandong University, Jinan, Shandong 250003, China. ^[4] the School of Medicine, Duke University, Durham, North Carolina 27705. ^[5] the Department of Pharmacology, Hebei Medical University, Shijiazhuang 050017, China. ^[6] the MOE Key Laboratory of Protein Science, School of Life Sciences, Tsinghua University, Beijing 100084, China jiaweiwu@mail.tsinghua.edu.cn. ^[7] From the Key Laboratory Experimental Teratology of the Ministry of Education, Department of Biochemistry and Molecular Biology, and sunjinpeng@sdu.edu.cn. ^[8] the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China, and. ^[9] the Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing 100191, China. ^[10]